Mpox diagnostics: Review of current and emerging technologies
Chuan Kok Lim1,2, Jason Roberts1,2, Michael Moso1,2
1Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Journal of Medical Virology
|December 26, 2022
Summary
Mpox virus (MPXV) is a zoonotic pathogen causing mpox outbreaks globally. This review covers MPXV virology, diagnostics, and genomics, crucial for understanding and controlling mpox spread.
Area of Science:
- Virology
- Genomics
- Epidemiology
Background:
- Mpox, caused by monkeypox virus (MPXV), is a zoonotic disease with recent unprecedented global transmission.
- Over 70,000 cases were reported worldwide by October 2022, raising concerns about endemicity outside traditional regions.
Purpose of the Study:
- To review current understanding of mpox virology and viral dynamics relevant to diagnostics.
- To outline traditional and emerging laboratory technologies for MPXV detection and elimination strategies.
- To discuss advancements in MPXV genomics and their impact on understanding viral evolution and adaptation.
Main Methods:
- Literature review of mpox virology, epidemiology, and diagnostics.
- Synopsis of traditional and emerging laboratory technologies for MPXV detection.
- Analysis of recent developments in MPXV genomics.
Main Results:
- MPXV virology and dynamics are critical for accurate mpox diagnostics.
- Various laboratory technologies exist for MPXV detection, aiding control efforts.
- Genomic studies have significantly advanced understanding of MPXV evolution during the recent outbreak.
Conclusions:
- Understanding MPXV virology, diagnostics, and genomics is essential for managing mpox.
- Technological advancements are key to effective MPXV detection and elimination strategies.
- Viral evolution and adaptation play a significant role in mpox epidemiology.
