Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

iPS Cell Differentiation01:22

iPS Cell Differentiation

2.8K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.1K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

24.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
24.3K
Stem Cell Culture01:17

Stem Cell Culture

5.3K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Contribution of tissue clearing and 3D image analysis to in vitro modeling of human cortical development.

Scientific reports·2026
Same author

Comparative Evaluation of DeepLabCut Convolutional Neural Network Architectures for High-Precision Markerless Tracking in the Mouse Staircase Test.

Bioengineering (Basel, Switzerland)·2026
Same author

Bilateral myelin oligodendrocyte glycoprotein antibody-associated disease after cataract surgery.

American journal of ophthalmology case reports·2026
Same author

The real-world effectiveness of defocus incorporated multiple segments and highly aspherical lenslets on myopia control: a longitudinal study from the French myopia cohort.

BMJ open ophthalmology·2025
Same author

Factors Affecting the Lifetime Cost of Myopia and the Impact of Active Myopia Treatments in Europe.

American journal of ophthalmology·2025
Same author

Electrophysiological characterisation of intranigral-grafted hiPSC-derived dopaminergic neurons in a mouse model of Parkinson's disease.

Stem cell research & therapy·2025

Related Experiment Video

Updated: Aug 16, 2025

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases
07:46

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

1.0K

Stem cell therapy in retinal diseases.

Audrey Voisin1, Amaury Pénaguin2, Afsaneh Gaillard3

  • 1Laboratoire de Neurosciences Expérimentales et Cliniques, Université de Poitiers, INSERM 1084; Department of Ophthalmology, CHU Poitiers, Poitiers, France.

Neural Regeneration Research
|December 26, 2022
PubMed
Summary

Stem cell therapies offer hope for retinal diseases like macular degeneration and retinitis pigmentosa, with ongoing research progressing from pre-clinical studies to human clinical trials for vision restoration.

Keywords:
age-related macular degenerationcell transplantationclinical trialretinal diseaseretinal dystrophystem cell

More Related Videos

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
05:09

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Published on: November 25, 2012

33.4K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K

Related Experiment Videos

Last Updated: Aug 16, 2025

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases
07:46

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

1.0K
Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye
05:09

Subretinal Injection of Gene Therapy Vectors and Stem Cells in the Perinatal Mouse Eye

Published on: November 25, 2012

33.4K
Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
07:43

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model

Published on: August 5, 2021

2.0K

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Cell Biology

Background:

  • Outer retinal diseases, including age-related macular degeneration and retinitis pigmentosa, cause vision loss and blindness.
  • Current treatments for retinal disorders are limited, necessitating novel therapeutic strategies.

Purpose of the Study:

  • To review the advancements in stem cell therapies for retinal diseases.
  • To cover the spectrum from pre-clinical research to clinical trials.

Main Methods:

  • Review of pre-clinical studies and human clinical trials involving stem cell transplantation for retinal diseases.
  • Focus on cell sources like embryonic stem cells, induced pluripotent stem cells, and multipotent stem cells.
  • Examination of retinal pigment epithelial cells and photoreceptors as primary targets for cell replacement.

Main Results:

  • Significant progress has been made in developing stem cell-based approaches for retinal repair.
  • Various stem cell types are being investigated for their potential to restore vision.
  • Clinical trials are evaluating the safety and efficacy of these therapies in patients.

Conclusions:

  • Stem cell therapy represents a promising frontier for treating currently incurable retinal diseases.
  • Continued research and clinical evaluation are crucial for realizing the full therapeutic potential of stem cells in ophthalmology.