Molecular hydrogen therapy for neurological diseases: a review of current evidence

Area of Science:

• Neuroscience
• Biochemistry

Background:

• Oxidative stress from reactive oxygen species contributes to neurological disease pathogenesis.
• Molecular hydrogen (H2) possesses selective free radical scavenging properties.

Purpose of the Study:

• To review animal and clinical studies on molecular hydrogen therapy's neuroprotective effects.
• To explore the anti-inflammatory and antioxidative mechanisms of H2 therapy.

Main Methods:

• Review of preclinical (animal) studies.
• Review of clinical trials.
• Analysis of implicated cellular pathways.

Main Results:

• H2 therapy demonstrated therapeutic potential in various neurological conditions.
• Evidence suggests H2 therapy exerts anti-inflammatory and antioxidative effects.
• Neuroprotective effects observed in stroke, neurodegenerative diseases, neurotrauma, and global brain injury models.

Conclusions:

• Molecular hydrogen therapy is a promising therapeutic strategy for neurological disorders.
• H2's selective antioxidant and anti-inflammatory actions underpin its neuroprotective capabilities.