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Tei Index Complements Conventional Echocardiographic Parameters in Diagnostic Workup of Suspected Takotsubo Syndrome

Moritz Mirna1, Fabian Vogl1, Lukas Schmutzler1

  • 1Department of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, Salzburg, Austria.

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
|December 26, 2022
PubMed

Insights

The Tei index (TI) effectively distinguishes Takotsubo syndrome (TTS) from acute coronary syndrome and controls. This cardiac function measure offers a sensitive and accessible tool for diagnosing TTS.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiac Physiology

Background:

  • The Tei index (TI) is a myocardial performance index assessing overall cardiac function.
  • Existing evidence on TI in Takotsubo syndrome (TTS) is limited.
  • Investigating TI's utility in TTS diagnosis is crucial.

Purpose of the Study:

  • To evaluate the Tei index (TI) for its ability to discriminate Takotsubo syndrome (TTS).
  • To compare TI's diagnostic performance against other echocardiographic parameters in TTS.

Main Methods:

  • Retrospective analysis of patients with TTS (n=51), acute coronary syndrome (ACS, n=29), and controls (n=58).
  • Analysis of laboratory and echocardiographic parameters, including TI.
  • Assessment of TI's discriminatory ability using area under the curve (AUC) and Youden index.

Main Results:

  • TI was significantly higher in TTS patients (median 0.516) compared to ACS (0.355) and controls (0.313) (p < 0.0001).
  • TI demonstrated superior discriminatory ability for TTS (AUC: 0.836, p < 0.0001).
  • A diagnostic cut-off for TTS was established at TI ≥0.418 (sensitivity: 74.0%, specificity: 83.5%).

Conclusions:

  • The Tei index (TI) exhibits superior discriminatory power for TTS compared to other echocardiographic parameters.
  • TI offers a simple, fast, and inexpensive method to aid in the diagnostic workup of suspected TTS.
  • TI can complement conventional parameters in the clinical evaluation of patients with suspected Takotsubo syndrome.
Abstract

Keywords:
Acute coronary syndromeMyocardial performance indexTakotsubo syndromeTei index

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