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Severe acute hepatitis of unknown origin
José L Pérez-Hernández1, Norma A Salgado-Galicia2, Raúl Carrillo-Esper3
1Liver Clinic, Hospital General de México "Dr. Eduardo Liceaga", Secretaría de Salud.
Gaceta Medica De Mexico
|December 26, 2022
Summary
Pediatric acute hepatitis cases in Europe were linked to adenovirus F41. Investigations ruled out COVID-19 and toxins, with some children needing liver transplants.
Area of Science:
- Hepatology
- Virology
- Pediatrics
Background:
- An unexplained outbreak of acute hepatitis in children occurred in the UK and Europe starting in 2022.
- Affected children under 10 presented with jaundice, nausea, vomiting, and liver failure, with some requiring liver transplantation.
Purpose of the Study:
- To investigate the etiology of the pediatric acute hepatitis outbreak.
- To identify the causative agent and rule out other potential factors.
Main Methods:
- Clinical data from affected pediatric patients were analyzed.
- Epidemiological investigation to identify potential etiological agents.
- Exclusion of toxic factors and association with COVID-19.
Main Results:
- Adenovirus genotype F41 is the probable etiological agent.
- Toxic factors and a link to COVID-19 were ruled out.
- The outbreak primarily affected children under 10 years of age.
Conclusions:
- Adenovirus F41 is strongly suspected as the cause of the pediatric hepatitis outbreak.
- Further research is ongoing to understand the exact mechanism and contributing factors.
- The findings highlight a significant public health concern requiring continued investigation.
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