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Theoretical model for the post-transcriptional regulation of the human c-myc gene expression, involving
P Gariglio1, R del Angel, A Herrera
1Department of Genetics and Molecular Biology, CINVESTAV-IPN, Mexico, D.F.
Journal of Theoretical Biology
|March 7, 1987
Abstract:
We propose that the human c-myc gene expression is regulated by a post-transcriptional mechanism based on the formation of a hairpin structure between c-myc mRNA exons 1 and 2. This structure could be rapidly processed by a hypothetical double stranded RNAse, removing the 5' end segment of the c-myc mRNA having the cap site. Removal of cap should propitiate exonucleolytic degradation of transcript.