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A haemochromatosis-causing HFE mutation is associated with SARS-CoV-2 susceptibility in the Czech population

J A Hubacek1, T Philipp2, V Adamkova3

  • 1Experimental Medicine Centre, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Department of Endocrinology and Metabolism, Third Department of Internal Medicine, First Faculty of Medicine, Charles University & General University Hospital, Prague, Czech Republic.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 26, 2022
PubMed

Insights

Genetic factors influence COVID-19 susceptibility. Individuals with the rs1800562 minor allele, linked to hereditary hemochromatosis and higher iron levels, show increased risk for SARS-CoV-2 infection.

Area of Science:

  • Genetics
  • Infectious Diseases
  • Human Physiology

Background:

  • Coronavirus disease (COVID-19) susceptibility is influenced by genetic factors, including those affecting iron metabolism.
  • Increased iron levels are associated with higher risk for SARS-CoV-2 infection.

Purpose of the Study:

  • To investigate the association between HFE gene variants, hereditary hemochromatosis, and COVID-19 susceptibility.
  • To determine if specific HFE genotypes impact SARS-CoV-2 infection risk and disease severity.

Main Methods:

  • Genotyping of HFE SNPs (rs1800562 and rs1799945) in 617 COVID-19 patients and 2,559 controls.
  • Analysis of allele frequencies and their correlation with infection status and disease severity.

Main Results:

  • The minor allele (Tyr282) of rs1800562 was more frequent in COVID-19 patients (8.5%) than controls (5.5%), indicating increased susceptibility (P < 0.002).
  • Non-carriers of the rs1800562 minor allele exhibited protection against SARS-CoV-2 infection (OR, 0.59).
  • The rs1799945 variant showed no significant effect on disease severity or susceptibility.

Conclusions:

  • The rs1800562 minor allele, associated with hereditary hemochromatosis and elevated iron, increases susceptibility to SARS-CoV-2 infection.
  • HFE genotype rs1800562 is a significant genetic determinant of COVID-19 risk.
Abstract

Keywords:
COVID-19HFEIronPolymorphismSusceptibility

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