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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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Clinical profile of patients with cardiac amyloidosis in India

Bishav Mohan1, Suvir Singh2, Rohit Tandon1

  • 1Dayanand Medical College & Hospital Unit Hero DMC Heart Institute, Ludhiana, India.

Indian Heart Journal
|December 26, 2022
PubMed

Insights

Cardiac amyloidosis (CA) is underdiagnosed in India. This study highlights high mortality and persistent symptoms in CA patients, suggesting a need for earlier diagnosis, especially in resource-limited settings.

Area of Science:

  • Cardiology
  • Amyloidosis Research
  • Indian Healthcare

Background:

  • Cardiac amyloidosis (CA) is a significant cause of heart failure, often underdiagnosed in India.
  • Limited data exists on the clinical presentation and outcomes of CA patients in the Indian subcontinent.
  • Late diagnosis contributes to poor prognosis in CA.

Purpose of the Study:

  • To present single-center data on cardiac amyloidosis patients in India.
  • To describe the clinical characteristics, outcomes, and diagnostic challenges of CA in this population.
  • To propose an algorithm for earlier CA diagnosis in resource-constrained environments.

Main Methods:

  • Retrospective analysis of 13 cardiac amyloidosis patients over four years.
  • Data collection included patient demographics, clinical presentation, diagnosis, and follow-up outcomes.
  • A diagnostic algorithm was developed based on clinical experience.

Main Results:

  • Median age of patients was 65 years; 69% presented with symptomatic heart failure.
  • Eight patients had confirmed light-chain (AL) amyloidosis.
  • Mortality was high (46%), with 30% dying within six months; 71% of survivors had persistent NYHA class III/IV symptoms.

Conclusions:

  • Cardiac amyloidosis in India is associated with significant morbidity and mortality.
  • Early diagnosis is crucial for improving patient outcomes.
  • The proposed algorithm may aid in earlier CA detection in resource-limited settings.

Keywords:
AmyloidCancerCardiacMyelomaTTR

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