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Metabolic reprograming of cancer as a therapeutic target

Tatsuhiko Furukawa1, Sho Tabata2, Kentaro Minami3

  • 1Department of Pathology, Graduate School Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan.

Biochimica Et Biophysica Acta. General Subjects
|December 26, 2022
PubMed

Insights

Cancer cells undergo complex metabolic reprogramming beyond the Warburg effect, presenting new therapeutic targets. Understanding these metabolic shifts is key to improving cancer treatments.

Area of Science:

  • Oncology
  • Metabolic pathways

Background:

  • Metabolic reprogramming in cancer is more complex than the classical Warburg effect.
  • Metabolic changes are increasingly explored as therapeutic and chemopreventive targets in cancer.
  • Clinical trials are investigating anti-cancer agents targeting cancer metabolism.

Approach:

  • Reviewing examples of cancer cell metabolic reprogramming.
  • Analyzing therapies targeting metabolism-related molecules.
  • Discussing approaches to enhance future cancer therapies focused on metabolic reprogramming.

Key Points:

  • Cancer metabolism is highly complex and adaptable.
  • Metabolic reprogramming is a hallmark of cancer.
  • Targeting cancer metabolism offers promising therapeutic strategies.

Conclusions:

  • Further research into the mechanisms of metabolic reprogramming is crucial.
  • Identifying downstream molecules can enhance cancer therapy effectiveness.
  • Next-generation cancer therapies should focus on metabolic reprogramming.
Keywords:
Anticancer agentClinical trialDrug discoveryMetabolic reprogramingTherapeutic target

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