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A model for oxygen storage by hemoglobin.

J M Colacino1, J R Brannan, M A Fields

  • 1Department of Biological Sciences, Clemson University, SC 29634-1903.

Journal of Theoretical Biology
|June 21, 1987
PubMed
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This study models biological oxygen (O2) storage using hemoproteins. It shows that O2 storage is feasible, with times up to 1,000 seconds achievable even in microscopic systems, primarily limited by diffusion.

Area of Science:

  • Biophysics
  • Physiology
  • Biochemistry

Background:

  • Intermittent hypoxia/anoxia poses challenges for organisms and tissues.
  • Oxygen (O2) storage via hemoproteins offers potential solutions.
  • Understanding the physical and chemical requirements for O2 storage is crucial.

Purpose of the Study:

  • To develop a model predicting oxygen storage time.
  • To analyze physical, chemical, and geometric factors influencing storage.
  • To explore limitations and possibilities of biological O2 storage.

Main Methods:

  • Development of a mathematical model for O2 storage time prediction.
  • Definition of storage time as 50% O2 diffusion from a loaded store in a zero-O2 environment.
  • Analysis of reaction-diffusion dynamics in hemoprotein-based systems.

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Main Results:

  • A wide range of biological O2 storage times are predictable with biological parameters.
  • Storage times approaching 1,000 seconds are achievable even for microscopic stores.
  • Biological O2 storage is predominantly diffusion-limited, but reaction-limited scenarios are possible.
  • Hemoglobin co-operativity influences O2 release rate: non-cooperative release declines, while cooperative release is constant.

Conclusions:

  • Biological O2 storage is a viable concept with significant potential.
  • Diffusion is the primary limitation, but reaction kinetics also play a role.
  • The model is applicable to various reaction-diffusion systems for substance storage.