Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Obstructive Pulmonary Disease-I: Introduction01:20

Chronic Obstructive Pulmonary Disease-I: Introduction

2.9K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.9K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

1.7K
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
1.7K
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

2.9K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
2.9K
Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies01:27

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

2.6K
Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes and treatment of early detectable donor-specific anti-HLA antibodies after lung transplantation: insights from a 12-year experience.

The Journal of thoracic and cardiovascular surgery·2026
Same author

Pulmonary Alveolar Proteinosis in Greece-Türkiye-Cyprus: Answers in a Real-Life Comparison.

Respirology (Carlton, Vic.)·2026
Same author

Exploring Social Determinants of Health in Primary Ciliary Dyskinesia.

Pediatric pulmonology·2026
Same author

Prevalence and disease trajectories of pulmonary fibrosis of childhood interstitial lung disease: a register-based, multicentre observational study.

The Lancet. Respiratory medicine·2026
Same author

Continued Nintedanib Treatment in Children and Adolescents With Fibrosing ILDs: Data From InPedILD-ON.

Pediatric pulmonology·2026
Same author

Expanding the clinical spectrum of RNU4ATAC-opathies: more frequent and diverse than assumed.

Genetics in medicine : official journal of the American College of Medical Genetics·2026

Related Experiment Video

Updated: Aug 16, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

50.2K

Minimal important difference in childhood interstitial lung diseases.

Matthias Griese1, Nicolaus Schwerk2, Julia Carlens2

  • 1Munich University Hospital, Dr von Hauner Children's Hospital, German Center for Lung Research (DZL), Munchen, Germany matthias.griese@med.uni-muenchen.de.

Thorax
|December 26, 2022
PubMed
Summary

This study establishes minimal important differences (MIDs) for vital signs and health-related quality of life (HrQoL) in childhood interstitial lung diseases (chILD). These findings aid clinicians in monitoring chILD progression and treatment effectiveness.

Keywords:
paediatric interstitial lung diseaserare lung diseases

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.1K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.5K

Related Experiment Videos

Last Updated: Aug 16, 2025

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

50.2K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.1K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

10.5K

Area of Science:

  • Pediatric Pulmonology
  • Clinical Research
  • Rare Diseases

Background:

  • Monitoring disease progression in childhood interstitial lung diseases (chILD) is crucial for effective patient management.
  • Minimal important difference (MID) data, representing the smallest clinically significant change, were previously unavailable for chILD vital signs and health-related quality of life (HrQoL).

Purpose of the Study:

  • To calculate and report MIDs for vital signs and HrQoL scores in a large cohort of children with chILD.
  • To provide clinicians with essential benchmarks for assessing treatment efficacy and disease progression in chILD patients.

Main Methods:

  • Utilized data from the Kids Lung Register, a web-based platform for rare pediatric lung disorders.
  • Calculated MIDs using both distribution-based (one-third SD) and anchor-based methods, with lung function parameters serving as anchors.
  • Collected data on vital signs (respiratory rate, oxygen saturation, Fan severity score) and various HrQoL questionnaires.

Main Results:

  • Established MIDs for respiratory rate (1.3 z-score), oxygen saturation (3.0%), and Fan severity score (0.2-0.4).
  • Determined MIDs for HrQoL scores, including the Health Status Questionnaire (0.4-0.8), chILD-specific questionnaire (4.4%-8.2%), and PedsQL V.4.0 subscores and total score.
  • Responsiveness analysis results generally aligned with the calculated MIDs.

Conclusions:

  • This study provides the first estimates of MIDs for vital signs and HrQoL in a substantial chILD cohort.
  • These MIDs serve as valuable tools for clinicians to interpret changes in patient status and make informed treatment decisions in chILD.