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Published on: April 8, 2013
Left ventricular aneurysm with predominating congestive heart failure. A comparative study of medical and surgical
Y Louagie1, T Alouini, J Lespérance
1Department of Surgery, Montreal Heart Institute, Quebec, Canada.
Insights
Surgical treatment for postinfarction left ventricular aneurysm improved survival-free complications but not overall survival in heart failure patients. This suggests surgery enhances quality of life and reduces cardiac risks compared to medical management.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Congestive heart failure (CHF) is a common complication of postinfarction left ventricular aneurysm.
- Patients with this condition often present with severe functional impairment, necessitating effective treatment strategies.
Purpose of the Study:
- To compare the long-term outcomes of surgical aneurysmectomy versus medical management in patients with CHF due to left ventricular aneurysm.
- To identify factors influencing survival and cardiac-related complications in this patient cohort.
Main Methods:
- A retrospective study of 109 patients treated between 1979 and 1985 for CHF caused by left ventricular aneurysm.
- Patients were divided into two groups: surgical (aneurysmectomy) and medical management.
- Follow-up averaged 48 months, with outcomes assessed using actuarial survival and complication-free rates.
Main Results:
- While 5-year survival rates were similar between surgical (70%) and medical (64%) groups, the complication-free rate was significantly higher in the surgical group (52% vs. 31%).
- Multivariate analysis identified surgical treatment, shorter interval from infarction to diagnosis, and absence of right ventricular failure as predictors of reduced cardiac complications and death.
- Functional improvement was directly linked to surgical treatment and residual segment contractile score.
Conclusions:
- Surgical treatment for left ventricular aneurysm in CHF patients improves quality of life and reduces cardiac complications.
- Surgery does not significantly increase overall survival compared to medical management but offers a better prognosis for cardiac-related events.
- Key factors for improved outcomes include surgical intervention and timely management post-infarction.
Abstract:
From 1979 to 1985, 109 patients were treated for congestive heart failure caused by postinfarction left ventricular aneurysm. Congestive heart failure was predominant in all patients at the time of diagnosis, 73% of whom were in Functional Class III or IV. Left ventricular end-diastolic pressure averaged 23.8 +/- 0.8 mm Hg (mean +/- standard error of the mean), total ejection fraction 29.7% +/- 1.0%, and telediastolic volume of the aneurysm 76.2 +/- 5.8 ml. Aneurysmectomy was performed in 49 patients (45%), whereas the remaining 60 patients were treated medically. The two groups did not differ in regard to clinical and hemodynamic data on admission, except for a more extensive coronary artery disease in the surgical group. Follow-up was obtained for all patients (100%) and averaged 48 +/- 3 months. Actuarial survival curves were similar, and the 5-year survival rates for surgical and medical groups were 70 +/- 7% and 64% +/- 7%, respectively (not significant). However, the 5-year complication-free rate was significantly (p = 0.05) higher among surgical patients (52% +/- 8%) than among the medical group (31% +/- 7%). Multivariate analysis showed the following variables to influence survival independently (p less than 0.05): contractile segment ejection fraction, right ventricular failure, antecedents of cardiac arrest or cardiogenic shock, and corrected contractile score. Independent variables decreasing the risk of cardiac-related complications and death (p less than 0.05) were as follows: surgical treatment, shorter interval between initial infarction and diagnosis of aneurysm, and absence of right ventricular failure. Functional improvement was directly related to surgical treatment and to residual segment contractile score (p less than 0.05). Thus, in patients with congestive heart failure caused by left ventricular aneurysm, surgical treatment improved the quality of life and prognosis for cardiac-related complications, but did not increase overall survival, compared to medical management of similar patients.
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