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Related Experiment Video

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Brain instability in dynamic functional connectivity in schizophrenia.

Thaise Graziele L de O Toutain1,2, José Garcia Vivas Miranda2, Raphael Silva do Rosário2

  • 1Postgraduate Program in Interactive Processes of Organs and Systems, Institute of Health Sciences, Federal University of Bahia, Salvador, Bahia, Brazil.

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|December 26, 2022
PubMed
Summary

Schizophrenia (SCZ) alters brain functional networks (BFNs), showing reduced temporal connectivity in temporal lobes but increased connectivity in central-parietal regions. Dynamic analysis reveals SCZ BFNs fluctuate, attempting but failing to maintain healthy connectivity patterns.

Keywords:
Brain functional networksBrain stabilityDynamic connectivityPsychosisSchizophreniaTime-varying graphs

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Computational Biology

Background:

  • Schizophrenia (SCZ) is linked to disrupted brain functional networks (BFNs), particularly in prefrontal-temporal interactions and hub regions.
  • Static analyses of BFNs miss dynamic functional structures like temporal connectivity and stability patterns.

Purpose of the Study:

  • To investigate dynamic brain connectivity processes in individuals with schizophrenia (SCZ) using resting-state EEG data.
  • To characterize temporal connectivity patterns and topological organization in SCZ BFNs.

Main Methods:

  • Acquired resting-state EEG data from 14 SCZ individuals and 14 healthy controls (HC) at 250 Hz.
  • Constructed dynamic BFNs using time-varying graphs and motif synchronization.
  • Evaluated connectivity indexes globally, by hemisphere, region, and electrode.

Main Results:

  • SCZ group showed lower temporal connectivity, reduced hub probability, and fewer edges in temporal lobes over time.
  • Increased temporal connectivity was observed in the central-parietal region for SCZ individuals.
  • No significant differences were found in full synchronization time or intra/inter-hemispheric connections between groups.

Conclusions:

  • SCZ BFNs exhibit dynamic fluctuations with abrupt connectivity increases, particularly in the temporal area.
  • These dynamic changes suggest an insufficient interaction to maintain healthy connectivity patterns in SCZ.
  • Dynamic analyses are crucial for a comprehensive understanding of brain alterations in schizophrenia over time.