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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

894

CD97 expression level and its effect on cell adhesion in Preeclampsia

Ayhan Atigan1, Semih Tan2, Hulya Cetin2

  • 1Department of Obstetrics and Gynecology, Faculty of Medicine, Karabuk University, School of Medicine, Karabuk, Turkey. dratigan@hotmail.com.

BMC Pregnancy and Childbirth
|December 26, 2022
PubMed

Insights

Preeclampsia (PE) involves altered cell adhesion molecules. CD97 levels were lower in PE patients, while E-cadherin was higher, suggesting a role in disease development.

Area of Science:

  • Obstetrics and Gynecology
  • Cell Biology
  • Immunology

Background:

  • Preeclampsia (PE) is a pregnancy complication characterized by cellular interactions and cell adhesion.
  • Understanding the molecular mechanisms of PE is crucial for developing effective diagnostic and therapeutic strategies.

Purpose of the Study:

  • To investigate the role of specific cell adhesion molecules, including CD97, neural (N)-cadherin, epithelial (E)-cadherin, and integrin beta-4, in the pathophysiology of preeclampsia.

Main Methods:

  • A prospective study involving 20 pregnant women with PE and 16 healthy pregnant women.
  • Analysis of standard blood tests (creatinine, uric acid, lactate dehydrogenase) and immunohistochemical staining of placental cell adhesion molecules.

Main Results:

  • PE patients exhibited higher creatinine, uric acid, and lactate dehydrogenase (LDH) levels.
  • CD97 maternal serum levels and placental expression were significantly lower in the PE group.
  • E-cadherin expression was significantly higher, while N-cadherin expression was significantly lower in the PE group. Integrin beta-4 showed no significant difference.

Conclusions:

  • Altered expression of cell adhesion molecules like CD97 and E-cadherin may contribute to preeclampsia, similar to their roles in cancer.
  • Restoring a balance in intercellular communication could be a potential therapeutic approach for preeclampsia.
Abstract

Keywords:
CD97CadherinsE-cadherinIntegrin beta-4N-cadherinPreeclampsia

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