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Identifying Coronary Artery Calcification on Non-gated Computed Tomography Scans
Published on: August 28, 2018
Epicardial fat volume evaluated with multidetector computed tomography and other risk factors for prevalence of
Bulang Gao1, Caiying Li2, Qibin Liao2
1Department of Neurosurgery, Shijiazhuang People's Hospital, 365 South Jianhua Street, Shijiazhuang, 050011, Hebei, China.
Insights
Greater epicardial fat volume and male gender are linked to prevalent three-vessel coronary lesions. This study investigated risk factors using multidetector computed tomography (MDCT) in 424 subjects.
Area of Science:
- Cardiology
- Radiology
- Biochemistry
Background:
- Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
- Epicardial fat volume (EFV) is an emerging marker associated with cardiovascular risk.
- Multidetector computed tomography (MDCT) allows for non-invasive assessment of cardiac structures and adipose tissue.
Purpose of the Study:
- To investigate the association between epicardial fat volume (EFV) and other risk factors with the prevalence of three-vessel coronary lesions.
- To identify predictors for significant coronary artery disease using MDCT and biochemical markers.
Main Methods:
- Retrospective analysis of 424 subjects undergoing MDCT.
- Measurement of epicardial fat volume (EFV) using MDCT.
- Analysis of blood parameters including lipids (HDL, LDL), apolipoproteins (ApoA, ApoB), and fasting blood glucose.
Main Results:
- Epicardial fat volume (EFV) showed a positive correlation with age and ApoB/ApoA ratio, and a negative correlation with HDL and ApoA.
- Patients with three-vessel coronary lesions had significantly greater EFV and fasting blood glucose compared to controls.
- Significant predictors for three-vessel coronary lesions included increased age, male gender, higher EFV, low HDL, high LDL, and elevated fasting blood glucose.
Conclusions:
- Increased epicardial fat volume (EFV) is a significant risk factor for three-vessel coronary lesions.
- Male gender is also associated with a higher prevalence of three-vessel coronary lesions.
- MDCT-derived EFV is a valuable tool in assessing cardiovascular risk.
Purpose:
To retrospectively investigate the epicardial fat volume with multidetector computed tomography (MDCT) and other risk factors for the prevalence of three-vessel coronary lesion.
Materials And Methods:
MDCT was performed on 424 subjects with or without three-vessel coronary lesion. Blood was tested for triglyceride, high-density lipoprotein (HDL), low-density lipoprotein (LDL), apolipoprotein A (ApoA), apolipoprotein B (ApoB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), lipoprotein a, and fasting blood glucose.
Results:
Among all the subjects, a significant (P < 0.05) negative linear correlation existed between age and ALT or ALT/AST. The epicardial fat had a significant (P < 0.05) negative linear correlation with HDL and Apo A but a positive correlation with age and ApoB/ApoA. The epicardial fat volume and the fasting blood glucose were significantly (P = 0.001) greater in the patients than in the control group, whereas HDL and Apo A were both significantly (P < 0.0001) smaller in the patients than in the control groups. A significant prediction value (P < 0.05) existed in age increase, male gender, epicardial fat increase, low HDL, high LDL, and elevated fasting blood glucose.
Conclusion:
Three-vessel coronary lesions are more prevalent in subjects with greater volume of epicardial fat and in male gender.
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