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Tamoxifen induced hands deformities
Yasmine Bendarkawi1,2, Ali Cherif Chefchaouni1,2, Sihame Lkhoyaali1,2
1Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Introduction:
Tamoxifen is widely used for the treatment of hormone-responsive breast cancer. In this article, we report a case of a patient who developed hand deformities following long-term administration of tamoxifen.
Case Report:
A 57-year-old woman, followed for invasive ductal carcinoma of the left breast under tamoxifen for 7 years, presenting joint pain with deformities in her fingers.
Management & Outcome:
Following the appearance of the adverse effect, tamoxifen was stopped. A series of biologic and radiologic analysis were performed in order to explain the appearance of this event. A substitution treatment was discussed and a rheumatologist's opinion was requested.
Discussion:
Tamoxifen appears to be associated with the development of inflammatory osteoarthritis resembling rheumatoid arthritis. Possible mechanisms of such an effect are discussed.
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