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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Updated: Aug 16, 2025

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Tamoxifen induced hands deformities.

Yasmine Bendarkawi1,2, Ali Cherif Chefchaouni1,2, Sihame Lkhoyaali1,2

  • 1Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
|December 27, 2022
PubMed
Summary

Long-term tamoxifen use for breast cancer can lead to inflammatory hand deformities. This condition mimics rheumatoid arthritis, prompting further investigation into tamoxifen

Keywords:
Tamoxifenbreast cancerrheumatoid arthritis

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Area of Science:

  • Oncology
  • Rheumatology
  • Pharmacology

Background:

  • Tamoxifen is a standard endocrine therapy for hormone-responsive breast cancer.
  • Long-term tamoxifen administration is associated with various side effects.

Observation:

  • A 57-year-old woman developed significant joint pain and finger deformities.
  • These symptoms emerged after 7 years of tamoxifen treatment for invasive ductal carcinoma.

Findings:

  • The patient's hand deformities and joint pain were clinically similar to rheumatoid arthritis.
  • Biologic and radiologic analyses were conducted to investigate the etiology of the adverse effect.

Implications:

  • Tamoxifen may be linked to the development of inflammatory osteoarthritis.
  • Understanding this association is crucial for managing long-term side effects in breast cancer survivors.
  • Further research into the mechanisms underlying tamoxifen-induced arthropathy is warranted.