Related Experiment Video
Updated: Aug 16, 2025
Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Challenges faced in developing an ideal chronic wound model
Mandy Li Ling Tan1,2, Jiah Shin Chin2, Leigh Madden2
1Nanyang Institute of Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 639798, Singapore.
Developing an ideal animal model for chronic wounds is crucial for advancing treatments. Current models inadequately represent human chronic wound complexity, hindering therapeutic development for these persistent, debilitating conditions.
Area of Science:
- Wound healing research
- Animal modeling
- Preclinical therapeutics
Background:
- Chronic wounds significantly impact patient quality of life and healthcare systems.
- An aging population and rising lifestyle diseases exacerbate the chronic wound burden.
- Existing animal models fail to fully replicate the complexity of human chronic wounds.
Conclusions:
- There is a critical need for more representative chronic wound animal models.
- Advancement of novel therapeutics to clinical application is hindered by inadequate models.
- Further research into alternative approaches for chronic wound modeling is warranted.
More Related Videos
07:32Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
09:06Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
Published on: March 25, 2020