Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Enterococcus faecium</i> colonization and persistence in a model of diabetic wound infection.

Infection and immunity·2026
Same author

Secretome from prolonged high-density human Wharton's jelly stem cell culture accelerates wound healing in both in vitro and in vivo models.

International wound journal·2025
Same author

Targeted Cx43 therapeutics reduce NLRP3 inflammasome activation in rat burn injury.

Burns : journal of the International Society for Burn Injuries·2025
Same author

Investigation of <i>Staphylococcus aureus</i> Biofilm-Associated Toxin as a Potential Squamous Cell Carcinoma Therapeutic.

Microorganisms·2024
Same author

Targeting Cx43 to Reduce the Severity of Pressure Ulcer Progression.

Cells·2023
Same author

Oxygenated Hydrogel Promotes Re-Epithelialization and Reduces Inflammation in a Perturbed Wound Model in Rat.

Journal of pharmaceutical sciences·2023
Same journal

Why Next-generation mechanistic models Will transform drug discovery: integrating efficacy and safety.

Expert opinion on drug discovery·2026
Same journal

Toward a nuanced framework for the Medical development of ibogaine and its analogues and derivatives: implications for psychopharmacology.

Expert opinion on drug discovery·2026
Same journal

From mitochondrial signal to discovery decision: a reserve-demand framework for translational risk assessment.

Expert opinion on drug discovery·2026
Same journal

Advances in 3D cell culture models for alzheimer's disease drug discovery.

Expert opinion on drug discovery·2026
Same journal

Are patient-derived models of amyotrophic lateral sclerosis a game changer for novel drug discovery?

Expert opinion on drug discovery·2026
Same journal

Unfolding prion misfolding and the challenge of identifying effective therapeutics: is there hope on the horizon?

Expert opinion on drug discovery·2026
See all related articles

Related Experiment Video

Updated: Aug 16, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.5K

Challenges faced in developing an ideal chronic wound model.

Mandy Li Ling Tan1,2, Jiah Shin Chin2, Leigh Madden2

  • 1Nanyang Institute of Health Technologies, Interdisciplinary Graduate School, Nanyang Technological University, 639798, Singapore.

Expert Opinion on Drug Discovery
|December 27, 2022
PubMed
Summary
This summary is machine-generated.

Developing an ideal animal model for chronic wounds is crucial for advancing treatments. Current models inadequately represent human chronic wound complexity, hindering therapeutic development for these persistent, debilitating conditions.

Keywords:
Animal modelsbiofilm infectionchronic woundsdelayed healing modelsdelayed wound closureexcessive extracellular matrix degradationhyper thickened epidermisincreased senescent cells populationpersistent inflammation

More Related Videos

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.8K

Related Experiment Videos

Last Updated: Aug 16, 2025

Protocol to Create Chronic Wounds in Diabetic Mice
06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.5K
Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
07:32

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair

Published on: February 17, 2021

7.4K
Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.
09:06

Assessment of Acute Wound Healing using the Dorsal Subcutaneous Polyvinyl Alcohol Sponge Implantation and Excisional Tail Skin Wound Models.

Published on: March 25, 2020

8.8K

Area of Science:

  • Wound healing research
  • Animal modeling
  • Preclinical therapeutics

Background:

  • Chronic wounds significantly impact patient quality of life and healthcare systems.
  • An aging population and rising lifestyle diseases exacerbate the chronic wound burden.
  • Existing animal models fail to fully replicate the complexity of human chronic wounds.

Conclusions:

  • There is a critical need for more representative chronic wound animal models.
  • Advancement of novel therapeutics to clinical application is hindered by inadequate models.
  • Further research into alternative approaches for chronic wound modeling is warranted.