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Inflammatory cytokines differ between patients with high versus low CHA2DS2-VASc scores in sinus rhythm-a possible

Avishag Laish-Farkash1, Ziv Sevilya1, Olga Perelshtein Brezinov1

  • 1Cardiology Department, Samson Assuta Ashdod University Medical Center, Ashdod, and Ben Gurion University of the Negev, Israel.

International Journal of Cardiology. Cardiovascular Risk and Prevention
|December 27, 2022
PubMed

Insights

Patients in sinus rhythm with high CHA2DS2-VASc scores exhibit elevated levels of inflammatory cytokines, suggesting a pro-inflammatory state that may contribute to adverse cardiovascular events.

Area of Science:

  • Cardiology
  • Inflammation Biology
  • Biomarkers

Background:

  • The CHA2DS2-VASc score predicts thromboembolism and mortality in patients with sinus rhythm (SR).
  • Previous studies indicated higher inflammatory markers (sP-selectin, C-reactive protein) in SR patients with high CHA2DS2-VASc scores.
  • This study further investigates inflammatory cytokine profiles in this patient group.

Purpose of the Study:

  • To investigate plasma concentrations of specific inflammatory cytokines in patients with sinus rhythm (SR) stratified by CHA2DS2-VASc score.
  • To determine if elevated CHA2DS2-VASc scores correlate with increased systemic inflammation markers in SR patients.

Main Methods:

  • Blood samples were collected from 66 consecutive patients in SR.
  • Plasma levels of IL-1β, IL-6, IL-8, IL-10, TNF-α, and VEGF were measured using Magnetic Luminex Performance Assay.
  • PF4 cytokine levels were determined by ELISA.

Main Results:

  • Patients with high CHA2DS2-VASc scores (n=23) showed significantly higher TNF-α levels compared to those with low scores (n=43).
  • A trend towards higher IL-1β and IL-8 levels was observed in the high CHA2DS2-VASc score group.
  • No significant differences in VEGF, IL-6, IL-10, and PF4 levels were found between the groups.

Conclusions:

  • Patients in SR with high CHA2DS2-VASc scores exhibit elevated plasma concentrations of systemic inflammatory cytokines, notably TNF-α.
  • This pro-inflammatory state may contribute to the increased risk of adverse cardiovascular events observed in these patients, even in the absence of atrial fibrillation.
  • Findings align with previous data on elevated sP-selectin and suggest a link between inflammation and cardiovascular risk in SR patients with high CHA2DS2-VASc scores.
Abstract

Keywords:
CHA2DS2-VASc scoreInflammationInflammatory cytokinesSinus rhythmTNF-α

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