Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

180
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
180
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

108
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
108
Cognitive Development During Adulthood01:30

Cognitive Development During Adulthood

199
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
199
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

721
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
721
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

549
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
549
Information Processing Approach01:30

Information Processing Approach

98
The information-processing theory of cognitive development centers on fundamental mental processes, including attention, memory, and problem-solving skills. Researchers in this field examine how cognitive abilities, such as working memory, evolve and influence children's overall development. Studies indicate that children with stronger working memory tend to excel in reading comprehension, math, and problem-solving compared to peers with less efficient memory skills. Low working memory is...
98

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Peripheral Nerve Stimulation of the Sacral Lateral Branches for Sacroiliac Joint Pain: A Technical Report.

Pain practice : the official journal of World Institute of Pain·2026
Same author

Updated 2026 Comprehensive Evidence-Based Guidelines for Facet Joint Interventions in the Management of Chronic Spinal Pain: American Society of Interventional Pain Physicians (ASIPP) Guidelines.

Pain physician·2026
Same author

Neurovascular Compression Syndromes of Cranial Nerves: A Multidisciplinary Guide to Management.

Brain sciences·2026
Same author

A Systematic Review and Meta-Analysis of Randomized Controlled Trials of Epidural Regenerative Medicine Therapies in Managing Spinal Pain.

Current pain and headache reports·2026
Same author

The Utility of Caudal Epidural Steroid Injections: A Comprehensive Review.

Orthopedic reviews·2026
Same author

Radiofrequency ablation of C2-3 medial branches/third occipital nerve to treat cervicogenic headache.

Annals of palliative medicine·2026
Same journal

17. Cancer Pain: Part I: Cordotomy for Unilateral Pain due to Cancer.

Pain practice : the official journal of World Institute of Pain·2026
Same journal

The False-Negative Paradox: Refining the Prognostic Value of Selective Nerve Root Blocks Before Pulsed Radiofrequency-A Comment on Van Ooijen Et al.

Pain practice : the official journal of World Institute of Pain·2026
Same journal

Palliative Analgesia in Patients With Childhood Cancer: A Retrospective Cohort Study.

Pain practice : the official journal of World Institute of Pain·2026
Same journal

Long-Term Effectiveness and Safety of Dorsal Root Ganglion Stimulation for Persistent Spinal Pain Syndrome: Results From an Expanded Prospective Registry.

Pain practice : the official journal of World Institute of Pain·2026
Same journal

Retrospective Assessment of Adjacent Fracture Risks in Vertebroplasty, Kyphoplasty, and Bone-Tumor Radiofrequency Ablation.

Pain practice : the official journal of World Institute of Pain·2026
See all related articles

Related Experiment Video

Updated: Aug 16, 2025

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

612

Chronic low back pain and cognitive function.

Alaa Abd-Elsayed1, Michael Gyorfi1

  • 1Department of Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.

Pain Practice : the Official Journal of World Institute of Pain
|December 27, 2022
PubMed
Summary
This summary is machine-generated.

Chronic low back pain negatively affects cognitive functions like problem-solving and memory. Effective pain management may improve cognitive abilities and reduce psychological distress in patients.

More Related Videos

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

775
Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

14.6K

Related Experiment Videos

Last Updated: Aug 16, 2025

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation
06:28

Biomechanical Changes Related to Low Back Pain: An Innovative Tool for Movement Pattern Assessment and Treatment Evaluation in Rehabilitation

Published on: December 13, 2024

612
Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model
07:34

Manual Therapy for a Chronic Non-Specific Low Back Pain Rat Model

Published on: August 11, 2023

775
Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

14.6K

Area of Science:

  • Neuroscience
  • Pain Medicine
  • Psychology

Background:

  • Chronic low back pain (CLBP) is a prevalent condition affecting millions globally.
  • CLBP is associated with significant impairments in cognitive functions, including executive functions and memory.
  • Psychological comorbidities, such as depression and anxiety, frequently co-occur with CLBP.

Purpose of the Study:

  • To investigate the multifaceted impact of CLBP on cognitive performance.
  • To explore the relationship between chronic pain intensity and specific cognitive deficits.
  • To examine the potential for pain treatment to ameliorate cognitive dysfunction in CLBP patients.

Main Methods:

  • Systematic review of existing literature on CLBP and cognitive function.
  • Meta-analysis of studies reporting on problem-solving, information processing speed, and memory recall in CLBP cohorts.
  • Comparative analysis of cognitive assessments in patients with and without CLBP.

Main Results:

  • Patients with CLBP demonstrate statistically significant deficits in problem-solving abilities.
  • Reduced speed of information processing is a common finding in individuals with CLBP.
  • Delayed memory recall is frequently observed in the CLBP population, suggesting broader cognitive impact.

Conclusions:

  • CLBP exerts a detrimental effect on multiple domains of cognitive function.
  • Effective management of chronic pain holds potential for cognitive rehabilitation.
  • Addressing pain and associated psychological factors is crucial for comprehensive patient recovery.