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Relation between thyroid hormonal status, neutrophillymphocyte ratio and left ventricular systolic function in

Mirela Halilčević1, Edin Begić2,3, Amela Džubur4

  • 1Department of Cardiology, Clinic for Heart, Blood Vessel and Rheumatic Diseases, Clinical Centre University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Medicinski Glasnik : Official Publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
|December 27, 2022
PubMed

Insights

Thyroid function and neutrophil-lymphocyte ratio (NLR) impact left ventricular ejection fraction (LVEF) in acute myocardial infarction patients. Hypothyroidism is linked to worse outcomes and more severe coronary artery disease.

Area of Science:

  • Cardiology
  • Endocrinology
  • Inflammation Research

Background:

  • Acute myocardial infarction (AMI) patients exhibit altered thyroid function and elevated inflammatory markers.
  • Left ventricular ejection fraction (LVEF) is a key indicator of cardiac function post-AMI.
  • The neutrophil-lymphocyte ratio (NLR) serves as a marker of systemic inflammation.

Purpose of the Study:

  • To investigate the relationship between thyroid function, NLR, and LVEF in AMI patients undergoing percutaneous coronary intervention (PCI).
  • To assess the association between thyroid status and the severity of coronary artery disease.

Main Methods:

  • Prospective study of 160 AMI patients, divided into euthyroid (n=80) and newly diagnosed hypothyroid (n=80) groups.
  • Analysis of thyroid hormones (TSH, T3, T4, FT3, FT4) and inflammatory markers (NLR, CRP).
  • Transthoracic echocardiography (TTE) to measure LVEF five days post-admission.

Main Results:

  • Significant differences in T3, T4, hematological parameters, NLR, CRP, and sedimentation rate between euthyroid and hypothyroid groups.
  • Euthyroid patients showed a higher frequency of single-vessel disease and lower frequency of triple-vessel disease.
  • LVEF significantly correlated with hemoglobin, NLR, and CRP; euthyroid patients had higher LVEF.

Conclusions:

  • Altered thyroid status in AMI is associated with coronary lesion severity and impaired LVEF.
  • Thyroid dysfunction correlates with the inflammatory response in AMI patients.
  • NLR and CRP are significant correlates of LVEF in this patient cohort.

Keywords:
myocardial infarctionprognosisrisk

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