The Impact of Cognitive Impairment on Postoperative Complications After Spinal Surgery: A Matched Analysis

The coprevalence of age-related comorbidities such as cognitive impairment and spinal disorders is increasing. No studies to date have assessed the postoperative spine surgery outcomes of patients with mild cognitive impairment (MCI) or severe cognitive impairment (dementia) compared with those without preexisting cognitive impairment.

Using all-payer claims database, 235,123 persons undergoing either cervical or lumbar spine procedures between January 2010 and October 2020 were identified. Exact 1:1:1 matching based on baseline patient demographics and comorbidities was used to create a dementia group, MCI group, and control group without MCI/dementia (n = 3636). The primary outcome was the rate of any 30-day major postoperative complications. Secondary outcomes included the rates of revision surgery, readmission rates within 30 days, and health care costs within 1 year postoperatively.

Compared with the control group, patients with dementia had an 8-fold and 5.4-fold increase in all-cause 30-day complications after undergoing cervical and lumbar spine procedures, respectively. Similarly, patients with MCI had a 3.1-fold and 2.2-fold increase in all-cause 30-day complications, respectively. Patients with either MCI or dementia had increased rates of pneumonia and urinary tract infection after either spine procedure compared with control (P < 0.01). Odds of revision surgery were increased in the lumbar surgery cohort for dementia (3.43; 95% confidence interval, 1.69-6.95) and for MCI (2.41; 95% confidence interval, 1.14-5.05).

This is the first study to characterize the postoperative complications profile of patients with preexisting dementia or MCI undergoing cervical and lumbar spine surgery. Both dementia and MCI are associated with increased postoperative complications within 30 days.