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Risk factors for early seizure after revascularization in patients with moyamoya disease
Hongchuan Niu1, Cunxin Tan1, Kehan Jin2
1Department of Neurosurgery, Peking University International Hospital, Beijing, China.
Background:
To investigate the risk factors for early seizure after revascularization in patients with moyamoya disease (MMD).
Methods:
A total of 298 patients with MMD diagnosed in our hospital from 2015 to 2018 were analyzed retrospectively. We summarized the characteristics of seizure after revascularization in patients with MMD and analyzed the predictors of early postoperative seizure.
Results:
We identified 15 patients with MMD who developed seizures within 1 week after revascularization. According to logistic regression analysis, age (OR: 1.04, 95% CI 0.998-1.086; P = 0.060) and infarct side (OR: 1.92, 95% CI 0.856-4.290; P = 0.113) were not significantly associated with incident early seizure. Postoperative infarction (OR: 12.89, 95% CI 4.198-39.525; P = 0.000) and preoperative cerebral infarction (OR: 4.08, 95% CI 1.267-13.119; P = 0.018) were confirmed as risk factors for early seizure.
Conclusions:
We believe that a history of preoperative infarction and new infarction are independent risk factors of early seizure in patients with MMD after revascularization.
Insights
Early seizures after revascularization in moyamoya disease (MMD) are linked to prior and new brain infarctions. These findings highlight key risk factors for postoperative seizure development in MMD patients.
Area of Science:
- Neurology
- Neurosurgery
- Vascular Neurology
Background:
- Moyamoya disease (MMD) is a rare cerebrovascular disorder.
- Revascularization surgery is a common treatment for MMD.
- Early seizures are a potential complication following revascularization in MMD patients.
Purpose of the Study:
- To identify risk factors for early seizure development after revascularization in moyamoya disease patients.
- To analyze predictors of early postoperative seizures in this patient cohort.
Main Methods:
- Retrospective analysis of 298 MMD patients diagnosed between 2015 and 2018.
- Identification of patients who experienced seizures within one week post-revascularization.
- Logistic regression analysis to determine significant predictors of early seizure.
Main Results:
- Fifteen patients (5%) developed seizures within one week of revascularization.
- Preoperative cerebral infarction (OR: 4.08) and postoperative infarction (OR: 12.89) were significant risk factors for early seizure.
- Age and infarct side were not significantly associated with early seizure development.
Conclusions:
- A history of preoperative infarction is an independent risk factor for early seizure post-revascularization in MMD.
- New postoperative infarction is also an independent risk factor for early seizure in MMD patients.
- These findings emphasize the importance of considering infarction history in managing MMD patients undergoing revascularization.
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