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Pyramidal multiple-theory (multi-type, multi-method and multi-layer) for facial fat grafting.
Hao Hu1, Yingshen Shi1, Yuxin Qian1
1Department of Plastic and Reconstructive Surgery, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
This study introduces a new approach to facial fat grafting that considers the complex anatomy of aging. By using different types of fat products and tailoring grafting techniques to specific facial zones, the researchers developed a more precise method for volume restoration. The strategy was tested in 58 patients, who reported high satisfaction and minimal complications. The approach allows for targeted rejuvenation of facial soft tissues, potentially offering better results than traditional techniques.
Area of Science:
- Plastic and reconstructive surgery
- Aesthetic medicine
- Tissue engineering and regenerative therapies
Background:
Facial aging involves complex anatomical and physiological changes across multiple tissue layers. While autologous fat grafting has become a standard in facial rejuvenation, the diversity of fat products and their specific applications remain underexplored. Prior research has shown that fat grafting can restore volume and improve facial contours, but the precise role of different fat types in various facial zones is not fully established. Surgeons often rely on generalized techniques, which may not address the layered nature of facial atrophy. This gap motivated the development of a more structured approach. The need for a systematic framework that integrates fat type, grafting method, and anatomical layer has been recognized. No prior work had resolved how to optimally combine these variables for facial rejuvenation. This paper introduces a novel strategy to address these limitations. The aim is to enhance both precision and patient outcomes in facial fat grafting.
Purpose Of The Study:
The study aimed to develop a structured facial fat grafting strategy that accounts for the anatomical complexity of aging. The researchers proposed a pyramidal multiple-theory approach, combining fat types, methods, and tissue layers. This strategy was designed to improve cosmetic outcomes by tailoring grafting to specific facial zones. The motivation stemmed from the limitations of traditional techniques, which often lack anatomical specificity. The authors sought to address the physiological changes in facial soft tissues more effectively. The goal was to enhance patient satisfaction while minimizing complications. The approach was tested in a clinical setting with a defined patient cohort. The results were compared to conventional methods to assess effectiveness.
Main Methods:
The study utilized a pyramidal multiple-theory framework for facial fat grafting. Different fat products, including Macrofat, Microfat, SEFF, nanofat, and SVF-gel, were selected based on their properties and intended use. The infiltration technique was adapted to specific anatomical zones of the face. Patients were categorized according to the facial regions requiring volume restoration. The grafting strategy involved layer-specific placement of fat products. Fifty-eight patients were treated between June 2020 and January 2022. Outcomes were assessed based on cosmetic improvements and patient satisfaction. Complications were monitored and recorded to evaluate the safety profile.
Main Results:
The pyramidal multiple-theory approach achieved cosmetic improvements in all 58 patients. Patient satisfaction was reported as high, with minimal complications observed. The use of different fat products allowed for targeted volume restoration across facial layers. Macrofat was used for deep volumetric support, while nanofat and SVF-gel were applied in superficial regions. The infiltration method was adjusted to match the anatomical structure of each facial zone. Post-treatment assessments showed consistent results across the cohort. No significant adverse effects were reported, supporting the safety of the approach. The results suggest that this strategy may offer better anatomical precision than traditional methods.
Conclusions:
The authors propose that the pyramidal multiple-theory approach provides a more anatomically informed method for facial fat grafting. The use of different fat types and infiltration techniques in specific facial zones may enhance cosmetic outcomes. The study suggests that this strategy addresses the physiological changes of aging more effectively than conventional methods. The authors note that the approach allows for tailored volume restoration based on facial anatomy. They emphasize the importance of matching fat product properties to the target tissue layer. The results indicate that patient satisfaction is high with minimal complications. The authors conclude that this method may represent an advancement in facial rejuvenation. Further research is not discussed in the abstract.
Frequently Asked Questions
The pyramidal multiple-theory is a structured approach that uses different fat types, methods, and tissue layers to address facial aging more precisely.
Macrofat, Microfat, SEFF, nanofat, and SVF-gel are selected based on their properties and intended anatomical placement.
The infiltration method is adapted to specific facial zones to ensure anatomical precision and optimal volume restoration.
Nanofat and SVF-gel are used in superficial facial layers to enhance rejuvenation and address soft-tissue atrophy.
Cosmetic improvements and patient satisfaction were assessed, with minimal complications reported across 58 patients.
The authors suggest that this strategy may offer better anatomical precision and patient outcomes compared to traditional methods.

