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Updated: Aug 15, 2025

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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Allogeneic bone marrow transplantation for aplastic anemia.

¹Fred Hutchinson Cancer Center and the University of Washington School of Medicine, 1100 Fairview Avenue N, D1-100, Seattle, WA, 98109, USA. rstorb@fredhutch.org.

International Journal of Hematology

|December 28, 2022

Summary

Allogeneic hematopoietic cell transplantation (HCT) has evolved into a standard treatment for aplastic anemia, offering better outcomes than immunosuppressive therapy. Advances in HLA typing and donor registries now allow nearly all patients to find a suitable donor for HCT.

Keywords:

Allogeneic hematopoietic cell transplantation Aplastic anemia Graft-versus-host disease

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Published on: December 8, 2023

Area of Science:

Hematology
Immunology
Transplantation Medicine

Background:

Allogeneic hematopoietic cell transplantation (HCT) has undergone significant evolution over 60 years.
Initially complex and risky, HCT is now a standard therapy for aplastic anemia.

Purpose of the Study:

To review the advancements in allogeneic HCT for aplastic anemia.
To highlight the progression from HLA-identical sibling donors to broader donor options.

Main Methods:

Review of historical data and recent breakthroughs in HCT donor selection.
Analysis of the impact of HLA typing and donor registries on HCT accessibility.

Main Results:

HCT has transitioned from a high-risk procedure to a preferred treatment for aplastic anemia.
Molecular HLA typing and volunteer registries have expanded donor options.
HLA-haploidentical HCT now enables donor availability for almost all patients.

Conclusions:

Allogeneic HCT is now a superior treatment option compared to immunosuppressive therapy for aplastic anemia.
Expanded donor options, including unrelated and haploidentical donors, have improved HCT accessibility and outcomes.