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Related Experiment Video

Updated: Aug 15, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

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Phase angle, nutritional status, and mortality in systemic sclerosis: An exploratory pilot study.

Edoardo Rosato¹, Antonietta Gigante¹, Chiara Pellicano¹

¹Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.

Nutrition (Burbank, Los Angeles County, Calif.)

|December 28, 2022

Summary

Bioelectrical impedance analysis-derived phase angle (PhA) is a nutritional indicator in Systemic sclerosis (SSc). Lower PhA values correlate with malnutrition risk and increased mortality in SSc patients.

Keywords:

Bioelectrical impedance analysis GLIM Malnutrition Phase angle Systemic sclerosis

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Area of Science:

Rheumatology
Clinical Nutrition
Biophysics

Background:

Systemic sclerosis (SSc) is a rare autoimmune disease causing microvascular damage and organ fibrosis.
Malnutrition is a common complication in SSc, negatively impacting quality of life and prognosis.
Nutritional status assessment is crucial for managing SSc patients.

Purpose of the Study:

To investigate bioelectrical impedance analysis-derived phase angle (PhA) as a nutritional status parameter in SSc.
To determine if PhA can serve as a marker of mortality in Systemic sclerosis patients.

Main Methods:

An exploratory pilot study included 104 adult SSc patients.
Nutritional status was assessed using the Malnutrition Universal Screening Tool (MUST) and Global Leadership Initiative on Malnutrition (GLIM) criteria.
Bioelectrical impedance analysis (BIA) was performed to obtain PhA values.

Main Results:

Lower PhA values were significantly associated with higher malnutrition risk (MUST) and malnutrition (GLIM) in SSc patients.
SSc patients with PhA < 3.75° had significantly shorter overall survival.
Multivariate analysis identified PhA as an independent predictor of mortality in SSc.

Conclusions:

Lower PhA is linked to increased malnutrition risk and mortality in Systemic sclerosis.
PhA may serve as a valuable tool for nutritional assessment and prognosis in SSc.
Further research is warranted to validate these findings.