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Correlation between serum zinc and testosterone: A systematic review.

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Zinc deficiency lowers testosterone levels in men. Supplementing with zinc can improve testosterone and androgen levels, with effects varying by dosage and duration.

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Area of Science:

  • Endocrinology
  • Trace Element Metabolism

Background:

  • Zinc is an essential trace element crucial for male reproductive health.
  • Testosterone, a key androgen hormone, plays a vital role in male physiological functions.
  • Maintaining adequate zinc levels is important for hormonal balance, particularly testosterone production.

Approach:

  • A systematic review and summary of 38 studies (8 clinical, 30 animal) investigating the relationship between zinc and serum testosterone.
  • Analysis of the effects of both dietary zinc deficiency and zinc supplementation on testosterone concentrations.

Key Points:

  • Zinc deficiency is associated with reduced serum testosterone levels.
  • Zinc supplementation demonstrates a positive impact on improving testosterone concentrations.
  • The magnitude of zinc's effect on testosterone is influenced by baseline levels, zinc dosage, and treatment duration.

Conclusions:

  • Serum zinc levels are positively correlated with total testosterone.
  • Moderate zinc supplementation is effective in enhancing androgen status in men.
  • Adequate zinc intake is vital for supporting healthy testosterone levels and male reproductive function.