Ni and O co-modified MoS₂ as universal SERS substrate for the detection of different kinds of substances

Surface-enhanced Raman scattering (SERS) has attracted extensive attention as an ultrasensitive detection method. However, the poor biocompatibility and expensive synthesis cost of noble metal SERS substrates have become non-negligible factors that limit the development of SERS technology. Metal chalcogenide semiconductors as an alternative to noble metal SERS substrates can avoid these disadvantages, but the enhancement effect is lower than that of noble metal substrates. Here, we report a method to co-modify MoS₂ by Ni and O, which improves the carrier concentration and mobility of MoS₂. The SERS effect of the modified MoS₂ is comparable to that of noble metals. We found that the improved SERS performance of MoS₂ can be attributed to the following two factors: strong interfacial dipole-dipole interaction and efficient charge transfer effect. During the doping process, the incorporation of Ni and O enhances the polarity and carrier concentration of MoS₂, enhances the interfacial interaction of MoS₂, and provides a basis for charge transfer. During the annealing process, the introduction of O atoms into the S defects reduces the internal defects of doped MoS₂, improves the carrier mobility, and promotes the efficient charge transfer effect of MoS₂. The final modified MoS₂ as a SERS substrate realizes low-concentration detection of bilirubin, cytochrome C, and trichlorfon. This provides promising guidance for the practical inspection of metal chalcogenide semiconductor substrates.