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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
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Single Cell Transcriptional Profiling of Adult Mouse Cardiomyocytes
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Multi-omics profiling visualizes dynamics of cardiac development and functions.

Yayun Gu1, Yan Zhou1, Sihan Ju2

  • 1State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, Jiangsu 211100, China; School of Public Health, Center for Global Health, Nanjing Medical University, Nanjing, Jiangsu 211100, China.

Cell Reports
|December 28, 2022
PubMed
Summary
This summary is machine-generated.

This study reveals key molecular players in heart development, identifying protein kinases and transcription factors essential for early cardiac growth and macrophages involved in postnatal heart repair.

Keywords:
CP: Developmental biologycardiac maturationcardiogenesisefferocytosismacrophagesmulti-omicsprotein phosphorylationtranscriptional regulation

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Area of Science:

  • Molecular Biology
  • Developmental Biology
  • Cardiovascular Research

Background:

  • Cardiogenesis, the process of heart formation, involves complex differentiation and proliferation.
  • The precise molecular mechanisms governing cardiogenesis and cardiac maturation are not fully elucidated.

Purpose of the Study:

  • To comprehensively dissect developmental changes during mouse heart formation and maturation.
  • To identify key molecular factors and regulatory networks involved in cardiogenesis and cardiac maturation using multi-omics approaches.

Main Methods:

  • Investigated mouse hearts from embryonic day 10.5 to postnatal week 8.
  • Performed phosphoproteome, proteome, metabolome, and transcriptome analyses.
  • Constructed reciprocal regulatory networks of transcription factors (TFs).

Main Results:

  • Identified mitogen-activated protein kinases (MAPKs) as core kinases regulating early cardiogenesis via chromatin remodeling protein phosphorylation.
  • Discovered transcription factors controlling early heart development and cycling-dependent proliferation.
  • Characterized cardiac resident macrophages with high arachidonic acid metabolism postnatally, potentially involved in clearing apoptotic cardiomyocytes.

Conclusions:

  • Comprehensive multi-omics data provide a detailed view of cardiac development and maturation.
  • The findings offer a valuable resource for further functional studies on heart development and repair.