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Prevalence and One-Year Survival of Selected Major Congenital Anomalies in Germany: A Population-Based Cohort Study

Salmai Turial1, Friederike Stimming1, Anke Lux2

  • 1Division of Pediatric Surgery, Pediatric Trauma Surgery and Pediatric Urology, University Medical Centre Magdeburg, Magdeburg, Germany.

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|December 28, 2022
PubMed

Insights

Infant survival rates for congenital anomalies in Saxony-Anhalt are comparable internationally, with 88.3% of live births surviving the first year. Comprehensive data including all pregnancy outcomes is crucial for accurate survival analysis.

Area of Science:

  • Pediatric Health
  • Public Health Surveillance
  • Medical Genetics

Background:

  • Congenital anomalies significantly contribute to global infant mortality.
  • Understanding prevalence and survival is key for public health interventions.
  • Saxony-Anhalt, Germany, serves as the study region.

Purpose of the Study:

  • To determine prevalence rates of major congenital anomalies.
  • To analyze 1-year survival rates for these anomalies.
  • To identify factors influencing infant survival.

Main Methods:

  • Systematic data collection by the Malformation Monitoring Centre Saxony-Anhalt.
  • Retrospective analysis of a cohort from 2000-2017.
  • Survival analysis including all pregnancy outcomes and risk factors.

Main Results:

  • 1,012 cases of congenital anomalies were registered.
  • Prevalence rates ranged from 2.5 (CDH) to 5.8 (SB) per 10,000.
  • Overall 1-year survival was 61.7% (including fetal losses), with 88.3% for live births.
  • Survival rates varied by anomaly type (35.7% for genetic, 57.6% for multiple, 68.6% for isolated).
  • Prenatally detected anomalies had lower survival (44.6%) than postnatally identified ones (85.2%).
  • Preterm birth (<31 weeks) and low birth weight (<1000g) adversely impacted survival.

Conclusions:

  • Survival rates in Saxony-Anhalt align with national and international findings.
  • Inclusion of all pregnancy outcomes (live birth, stillbirth, fetal loss) is vital for accurate statistical analysis in malformation registers.
Abstract

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