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Related Experiment Videos

Methodological approaches to primate behavioral toxicological testing.

D C Rice1

  • 1Toxicology Research Division, Health Protection Branch, Ottawa, Canada.

Neurotoxicology and Teratology
|March 1, 1987
PubMed
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Monkeys serve as excellent models for studying low-level neurotoxicant effects on developing nervous systems. Behavioral tests reveal subtle impairments from lead and methylmercury, mirroring human developmental neurotoxicity.

Area of Science:

  • Neuroscience
  • Developmental Toxicology
  • Behavioral Pharmacology

Background:

  • The non-human primate nervous system closely resembles the human, making it a valuable model for neurodevelopmental studies.
  • Monkeys share humans' prolonged developmental periods, crucial for understanding the impact of early-life exposures.
  • Unique sensory and cognitive systems in monkeys allow for detailed investigation of neurotoxicant effects.

Purpose of the Study:

  • To characterize low-level neurotoxicant effects on the developing nervous system using a primate model.
  • To assess subtle neurodevelopmental deficits induced by environmental toxins like lead and methylmercury.
  • To evaluate the utility of behavioral and psychophysical techniques in detecting neurotoxicity.

Main Methods:

Related Experiment Videos

  • Utilized cynomolgus monkeys for developmental neurotoxicity studies.
  • Employed operant conditioning techniques and intermittent schedules to detect subtle behavioral defects.
  • Applied cognitive tests (discrimination reversal, matching to sample, delayed alternation) and psychophysical methods.

    • Main Results:

    • Developmental lead exposure in monkeys produced cognitive impairments (learning, memory, adaptability, distractibility) similar to affected children.
    • Psychophysical techniques identified visual deficits from methylmercury exposure, even without overt toxicity signs.
    • Behavioral pharmacology tools proved sensitive in detecting neurotoxicant-induced impairments.

    Conclusions:

    • Monkeys are highly suitable models for investigating low-level developmental neurotoxicant effects.
    • Behavioral and psychophysical assessments can reveal subtle neurodevelopmental toxicity.
    • Findings highlight similarities between primate and human responses to neurotoxicants like lead and methylmercury.