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Published on: November 28, 2018
ClotPro Viscoelastometry Evaluation in Cardiac Surgery With Cardiopulmonary Bypass
David Núñez-Jurado1, José D Santotoribio1, José Á Noval-Padillo1
1Department of Clinical Biochemistry, Virgen del Rocío University Hospital, Seville, Spain.
Objective:
The aim of this study was to assess the reproducibility of the new viscoelastic analyzer ClotPro, and compare the parameters this system produces with the ROTEM delta system in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
Design:
A prospective and observational study.
Setting:
At a university hospital.
Participants:
Forty adult patients undergoing cardiac surgery with CPB.
Interventions:
Correlations were calculated between ClotPro and ROTEM delta parameters.
Measurements And Main Results:
The ClotPro showed a high reproducibility in most of the parameters of each test; whereas ROTEM delta, although showing a low coefficient of variation in the parameters related to clot firmness, showed a high variability in the coagulation times. Excellent correlations were observed in most of the parameters of each test between ROTEM delta and ClotPro (≥0.93). However, a moderate correlation was obtained between the clotting time of the EXTEM and the EX-test (0.54). The concordance of amplitudes at different times within each test was almost 100% on both thromboelastometers. Regarding absolute differences in the test results, most of the measurements showed significant differences (p < 0.0001) between both devices.
Conclusions:
ClotPro can be used as an alternative to ROTEM delta to evaluate coagulation function in cardiac surgery, but specific reference ranges need to be established first.
