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Regulation of DC metabolism by nitric oxide in murine GM-CSF cultures
Lucía Minarrieta1, Gloria J Godoy2, Lis N Velazquez2
1Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Canada.
European Journal of Immunology
|December 28, 2022
Abstract:
The CD11c+ MHCII+ compartment within GM-CSF cultures consists of a MHCIIlow CD11bhigh population (GM-Macs) and a MHCIIhigh CD11bint population (GM-DCs), with different metabolic profiles. GM-Macs upregulate iNOS and produce nitric oxide (NO) upon TLR activation inhibiting mitochondrial respiration (OXPHOS) while promoting glycolytic metabolism in GM-DCs, which naturally do not express iNOS.
