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Changes in ocular biological parameters after cycloplegia based on dioptre, age and sex

Yulin Tao1,2, Xiaokang Cheng1, Can Ouyang1

  • 1Department of Ophthalmology, Jiujiang No 1 Peoples Hospital, Affiliated Jiujiang Hospital of Nanchang University, 48 South Taling Road, Jiujiang, 332000, Jiangxi, China.

Scientific Reports
|December 28, 2022
PubMed

Insights

Cycloplegia significantly alters ocular biometry in children, with changes in axial length, corneal thickness, and anterior chamber depth varying by refractive error, age, and sex. These findings highlight the importance of considering cycloplegia

Area of Science:

  • Ophthalmology
  • Pediatric Eye Care
  • Ocular Biometry

Background:

  • Cycloplegia's impact on ocular parameters is known, but comparative studies across refractive states, ages, and sexes are limited.
  • Understanding these variations is crucial for accurate pediatric eye assessments.

Purpose of the Study:

  • To investigate changes in ocular biometry before and after cycloplegia.
  • To compare these changes across different refractive states (dioptre), age groups, and sexes.

Main Methods:

  • A cross-sectional study of 2049 participants.
  • Ocular parameters (axial length, keratometry, corneal thickness, anterior chamber depth, white-to-white distance) measured before and after cycloplegia using atropine or tropicamide.
  • Statistical analysis using paired t tests and Wilcoxon signed-rank tests.

Main Results:

  • Axial length increased significantly post-cycloplegia in specific refractive groups. Significant increases in keratometry and anterior chamber depth were noted in the 'Fs' group.
  • Age-related differences observed: axial length increased in younger children but decreased in older groups. Central corneal thickness and anterior chamber depth increased in one age group.
  • Sex-based differences: axial length and white-to-white distance decreased in males and increased in females, with opposing trends in keratometry.

Conclusions:

  • Cycloplegia induces significant changes in ocular biological parameters, notably axial length, central corneal thickness, and anterior chamber depth.
  • These effects vary considerably based on refractive state, age, and sex.
  • Clinicians must consider the influence of cycloplegia during eye examinations, especially in pediatric populations.

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