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Updated: Aug 15, 2025
An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
Published on: January 27, 2010
Association between ABO blood groups and postoperative pain in children after adenotonsillectomy: a prospective
Longyuan Shen1, Jianwen Wu1, Quansheng Xiao1
1Department of Anesthesiology, Quanzhou Women's and Children's Hospital, Fujian Province, Quanzhou, China.
Insights
Children with AB and B blood types experienced greater postoperative pain and required more fentanyl after adenotonsillectomy compared to those with A or O blood types. This suggests a link between ABO blood groups and pediatric pain management needs.
Area of Science:
- Anesthesiology
- Pediatric Surgery
- Genetics
Background:
- ABO blood groups are associated with various disease phenotypes.
- The relationship between ABO blood groups and pediatric postoperative pain is not well-established.
- Adenotonsillectomy is a common pediatric surgical procedure.
Purpose of the Study:
- To investigate the association between ABO blood groups and postoperative pain in children undergoing adenotonsillectomy.
- To compare pain scores and analgesic requirements across different ABO blood groups.
- To explore potential differences in emergence delirium and recovery time based on blood type.
Main Methods:
- 124 children (3-7 years, ASA I/II) undergoing elective adenotonsillectomy were enrolled.
- Postoperative pain assessed using the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS).
- Fentanyl consumption, Pediatric Anesthesia Emergence Delirium (PAED) scores, and PACU duration were recorded.
Main Results:
- Patients with AB and B blood groups reported significantly higher initial CHEOPS pain scores.
- Higher rescue fentanyl requirements were observed in AB and B blood groups during the post-anesthesia care unit (PACU) stay.
- Elevated PAED scores were also noted in children with AB and B blood types.
Conclusions:
- Pediatric patients with AB and B blood types experience more intense postoperative pain after adenotonsillectomy.
- These patients require significantly higher doses of fentanyl for effective pain management.
- ABO blood type may influence pain perception and analgesic needs in the pediatric population.
Background:
It has been known that ABO blood groups are linked to the phenotypes of certain diseases; however, and the relationship between ABO blood groups and postoperative pain have not been extensively studied, especially in children. This study was to investigate whether there would be an association between the four major ABO blood groups and postoperative pain, as indicated by the differences in pain scores and rescue fentanyl requirements among blood groups in children after adenotonsillectomy.
Methods:
A total of 124 children, aged 3-7 years, ASA I or II, and undergoing elective adenotonsillectomy were enrolled in the study. Postoperative pain was evaluated using the Children's Hospital of Eastern Ontario Pain Scale (CHEOPS) and the rescue fentanyl requirement in post anesthesia care unit (PACU) was analyzed. Pediatric Anesthesia Emergence Delirium (PAED) score and the duration of PACU were recorded. The postoperative nausea and vomiting (PONV) within 24 h were documented.
Results:
Among four blood type groups, no significant differences were observed regarding surgery time, and the gaps of fentanyl given at the anesthesia induction and the first rescue fentanyl injection in PACU. However, patients from AB and B blood groups had significantly higher pain score at initial CHEOPS assessment and consequently, higher consumption of rescue fentanyl during PACU stay. A significantly higher percentage of patients had received > 1 μg/kg rescue fentanyl. Higher PAED scores were also observed in AB and B blood groups.
Conclusion:
Paediatric patients with AB and B blood type had higher postoperative CHEOPS pain score and required significantly more fentanyl for pain control than those with A and O blood type after T&A. The initial scores of PAED in patients with AB and B blood type were also higher than that in patients with A and O blood type.
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