Controlled Iodine Phase Transfer of Covalent Organic Framework Membranes for Instant but Sustained Disinfection

Freestanding membranes of CuCl₂-implanted TpPa covalent organic frameworks (COFs) were mechanochemically produced. The resulting membrane had a high I₂ adsorption capacity (566.78 g·mol^-1) in cyclohexane, which corresponds to 2.2I₂ per unit cell with 1.3I₂ immobilized on 3Cl^- ions (60%) and 0.9 on 3N atoms (40%). Upon being placed in aqueous media, the membrane released 61.1% of its loaded I₂ mainly by its Cl^- ions within 10 min and the remaining 38.9% mainly from its N atoms within about 5 h. Thanks to that, the COF membranes loaded with 1.5 mg of I₂ could be repetitively utilized to kill about 10⁸ CFU/mL E. coli in 0.5-3 min at least five times, after which the membranes could retain their bactericidal activity for 4 h against 10⁸ CFU/mL E. coli. This highlights the promising application of I₂-loaded TpPa-CuCl₂ COF membranes for instant and sustained disinfection.