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Distinct urinary progesterone metabolite profiles during the luteal phase
Saman Abdullah1, Thomas Bouchard2, René Leiva3,4
1Department of Statistics and Information, College of Administration and Economics, University of Sulaimani, Sulaymaniyah, Iraq.
Hormone Molecular Biology and Clinical Investigation
|December 29, 2022
Summary
Urinary pregnanediol glucuronide profiles during the luteal phase vary, correlating with early hormone changes. These distinct patterns offer insights for progesterone testing timing in clinical practice.
Area of Science:
- Reproductive Endocrinology
- Hormone Monitoring
Background:
- Serum progesterone levels exhibit significant variability during normal menstrual cycles.
- Understanding luteal phase hormone dynamics is crucial for reproductive health assessment.
Purpose of the Study:
- To investigate and classify distinct pregnanediol glucuronide profiles during the luteal phase.
- To examine associations between these profiles and other hormonal changes.
Main Methods:
- Analysis of data from 107 women and 326 menstrual cycles.
- Monitoring cervical mucus, urinary hormones, and serum progesterone.
- Utilizing transvaginal ultrasonography to identify ovulation day.
Main Results:
- Low periovulatory pregnanediol glucuronide and luteinizing hormone (LH) levels correlated with delayed post-ovulatory increases.
- 'Delayed increase' and 'plateau-like' pregnanediol glucuronide profiles were associated with specific hormonal patterns and cycle lengths.
Conclusions:
- Distinct urinary pregnanediol glucuronide profiles characterize the luteal phase.
- These profiles are linked to early hormonal fluctuations within the menstrual cycle.
- Findings support progesterone testing seven days post-mucus peak for clinical utility.
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