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Acute Pancreatitis I: Introduction

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:

Acute Pancreatitis II: Clinical Manifestations and Management

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...

Chronic Pancreatitis I: Introduction

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

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Related Experiment Video

Updated: Aug 15, 2025

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

Circulating monocytes in acute pancreatitis.

Shiyu Liu¹, Peter Szatmary², Jing-Wen Lin³

¹West China Centre of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China-Liverpool Biomedical Research Centre, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in Immunology

|December 29, 2022

Summary

Monocytes are key players in acute pancreatitis, driving inflammation and organ failure. This review explores how changes in monocyte numbers, types, and functions, influenced by lipids, impact this condition.

Keywords:

acute pancreatitis animal models hypertriglyceridemia immunity inflammation lipotoxicity monocytes obesity

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Last Updated: Aug 15, 2025

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Published on: May 10, 2024

Area of Science:

Gastroenterology
Immunology
Pathophysiology

Background:

Acute pancreatitis is a prevalent gastrointestinal disease causing pancreatic inflammation and abdominal pain.
It often leads to organ failure, pancreatic necrosis, and mortality.
Monocytes, crucial innate immune cells, are increasingly recognized for their role in pancreatitis pathogenesis.

Purpose of the Study:

To review recent advancements in understanding monocyte dynamics during acute pancreatitis.
To elucidate the regulatory mechanisms governing monocyte behavior in this condition.
To emphasize the impact of lipid modulation on monocyte function in acute pancreatitis.

Main Methods:

Literature review of recent studies on monocytes in acute pancreatitis.
Analysis of data on monocyte number, phenotype, and function changes.
Focus on regulatory mechanisms and lipid modulation.

Main Results:

Circulating monocyte numbers, phenotypes, and functions dynamically change during acute pancreatitis.
These changes are intricately regulated, involving various signaling pathways.
Lipid modulation significantly influences monocyte behavior and inflammatory responses.

Conclusions:

Monocytes are critical regulators of the inflammatory cascade in acute pancreatitis.
Understanding monocyte dynamics and regulatory mechanisms offers therapeutic targets.
Lipid modulation presents a promising avenue for managing acute pancreatitis.