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Kratom-induced common bile duct dilation.

Marjan Haider1, Neil Shah1, Ali Yazdani1

  • 1Department of Internal Medicine, St. Joseph Mercy Ann Arbor Hospital , Ann Arbor , Michigan.

Proceedings (Baylor University. Medical Center)
|December 29, 2022
PubMed
Summary
This summary is machine-generated.

Kratom, an herb with opioid-like effects, is increasingly used for pain and opioid withdrawal. This case study links kratom use to common bile duct dilation, potentially due to its mu-opioid agonism.

Keywords:
Bile duct dilationkratomopioid

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Area of Science:

  • Pharmacology
  • Gastroenterology
  • Toxicology

Background:

  • Kratom (Mitragyna speciosa) is an herbal substance with psychoactive properties, increasingly used in the US for pain and opioid dependence management.
  • Its mu-opioid agonism is recognized, but its effects on the biliary system are not well-documented.

Observation:

  • A case of common bile duct dilation is presented in a patient using kratom.
  • The patient's presentation and imaging findings suggested a link between kratom consumption and biliary ductal changes.

Findings:

  • Kratom use was identified as a potential causative factor for common bile duct dilation.
  • The mechanism is hypothesized to involve mu-opioid agonism, mirroring effects seen with opiate-induced biliary changes.

Implications:

  • This finding highlights a potential adverse effect of kratom, specifically on the biliary system.
  • Further research is warranted to understand the prevalence and mechanisms of kratom-induced hepatobiliary complications.
  • Clinicians should consider kratom use in patients presenting with unexplained biliary dilation.