Related Experiment Video

Updated: Aug 15, 2025

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment
03:32

Single Incision Plus One Port Laparoscopic Proximal Gastrectomy with Double Channel Anastomosis for Gastric Cancer Treatment

Published on: December 27, 2024

865

The multivariate cox regression model for complete enteral nutrition after primary anastomosis in neonates with

Yang Chen1,2, Le-Dao Zhu1, Ling Zhou1

  • 1Shenzhen Children's Hospital, Shenzhen, China.

Frontiers in Pediatrics
|December 29, 2022
PubMed

Insights

This study developed a prediction model for complete enteral nutrition in neonates with intestinal atresia. Key factors like gestational age and feeding time help predict outcomes, aiding clinical decisions.

Area of Science:

  • Pediatric Surgery
  • Neonatal Nutrition
  • Clinical Prediction Modeling

Background:

  • Enteral feeding following intestinal atresia repair presents clinical challenges.
  • Existing research often focuses on isolated factors, lacking a comprehensive approach.

Purpose of the Study:

  • To comprehensively analyze multiple factors influencing complete enteral nutrition after primary intestinal anastomosis.
  • To establish a convenient and accurate prediction model for enteral feeding success in neonates.

Main Methods:

  • Retrospective analysis of neonatal intestinal atresia cases (January 2010 - June 2022).
  • Cox regression analysis to identify independent risk factors.
  • Development and validation of a nomogram using ROC, calibration, and decision curves.

Main Results:

  • Identified key predictors: gestational age, meconium peritonitis, anastomosis-to-ileocecal region distance, proximal-to-distal bowel diameter ratio, and initial feeding time.
  • Nomogram demonstrated strong predictive performance with AUCs of 0.765 (week 2), 0.785 (week 3), and 0.747 (week 4).
  • Calibration and decision curves confirmed the model's accuracy and clinical applicability.

Conclusions:

  • The developed prediction model holds significant clinical value for managing enteral feeding in neonates with intestinal atresia.
  • This tool can assist pediatricians in optimizing patient care, potentially reducing hospital costs and parental anxiety.
Abstract

Keywords:
cox regressionenteral nutritionintestinal atresianomogramprimary anastomosis

More Related Videos

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice06:40

Single-Anastomosis Duodeno-Ileal Bypass with Sleeve Gastrectomy Model in Mice

Published on: February 10, 2023

1.6K
An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function09:40

An Ivor Lewis Esophagectomy Designed to Minimize Anastomotic Complications and Optimize Conduit Function

Published on: April 17, 2020

13.7K

Related Concept Videos

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding01:15

Enteral Nutrition II: Nasointestinal and Gastrostomy Feeding

Enteral nutrition encompasses various methods of delivering nutrition directly to the gastrointestinal (GI) tract, bypassing traditional oral intake. It is particularly beneficial for patients who cannot eat by mouth but have a functioning digestive system. Key methods include nasointestinal feeding, gastrostomy, and jejunostomy, each suited to different clinical scenarios based on the patient's needs and condition.
Nasointestinal Feeding
Nasointestinal feeding involves placing a tube...
244
Enteral Nutrition I: Orogastric and Nasogastric Feeding01:26

Enteral Nutrition I: Orogastric and Nasogastric Feeding

Enteral nutrition delivers nutrients directly to the stomach or small intestine through a tube. This method is appropriate for patients who cannot eat but still have a functioning digestive system. It is also beneficial for individuals with swallowing difficulties, anorexia, malabsorption, or those who have undergone gastrointestinal (GI) surgery.
Orogastric (OG) and nasogastric (NG) feeding are two standard methods used for enteral nutrition. Enteral nutrition is often preferred over...
418
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
386
One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model01:12

One-Compartment Open Model for Extravascular Administration: Zero-Order Absorption Model

Extravascular administration, such as oral or intramuscular routes, is a non-invasive drug delivery method, often preferred for ease and patient compliance. A key factor here is absorption, which dictates how quickly and effectively the drug enters the bloodstream from the administration site. Absorption follows either zero-order or first-order kinetics.
Zero-order absorption maintains a steady rate irrespective of the amount of drug left to be absorbed, making it a constant process. In the...
137
One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance00:56

One-Compartment Open Model for IV Bolus Administration: Estimation of Clearance

Clearance is a key pharmacokinetic parameter that quantifies the volume of body fluid from which a drug is entirely removed within a specific time frame. It is crucial in assessing how a drug is eliminated from the body and has critical clinical applications.
In the one-compartment open model for intravenous (IV) bolus administration, clearance is estimated by dividing the elimination rate by the plasma drug concentration. This equation leverages the elimination rate constant and the apparent...
121
Two-Compartment Open Model: IV Bolus Administration01:18

Two-Compartment Open Model: IV Bolus Administration

The two-compartment model for intravenous (IV) bolus administration illustrates drug distribution in the body, subdividing it into central and peripheral compartments. This model operates on the concept of two-compartment kinetics. The drug's plasma concentration shows a bi-exponential decline following IV bolus administration, signaling the presence of two disposition processes: distribution and elimination.
The disparity between drug input and the sum of drug transfer rates between...
648