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Updated: Aug 15, 2025

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

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Apoptosis regulation by the tyrosine-protein kinase CSK

Andra Fortner1,2, Alexandra Chera1,3, Antoanela Tanca1,3

  • 1Victor Babes National Institute of Pathology, Bucharest, Romania.

Frontiers in Cell and Developmental Biology
|December 29, 2022
PubMed

Insights

C-terminal Src kinase (CSK) regulates cell fate by inhibiting SRC family kinases (SFKs), impacting apoptosis and proliferation. Dysregulation of CSK and SFKs is linked to various diseases, including cancer and neurological disorders.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • C-terminal Src kinase (CSK) is a key regulator of cellular processes, including apoptosis, survival, and proliferation.
  • CSK primarily functions by negatively regulating SRC family kinases (SFKs) through phosphorylation.
  • The precise mechanisms, regulation, and diverse functions of CSK are still under active investigation.

Purpose of the Study:

  • To review the role of CSK in apoptosis regulation.
  • To elucidate the mechanisms by which CSK inhibits SFKs.
  • To explore the clinical relevance of CSK in various pathologies.

Main Methods:

  • Literature review of studies on CSK and SFK.
  • Analysis of signaling pathways regulated by CSK and SFKs (e.g., MAPK/ERK, STAT3, PI3K/AKT).
  • Examination of clinical data linking CSK/SFK dysregulation to disease.

Main Results:

  • CSK inhibition of SFKs induces a pro-apoptotic effect.
  • CSK-mediated SFK inhibition impacts critical signaling cascades.
  • Abnormal CSK and SFK activity are implicated in cancer, cardiovascular, and neurological diseases.

Conclusions:

  • CSK plays a crucial role in controlling cell death and survival through SFK regulation.
  • Understanding CSK's function is vital for developing therapeutic strategies for diseases driven by SFK dysregulation.
  • CSK's involvement extends to cancer, autoimmune disorders, and neurological conditions.
Keywords:
CskMAPK pathwayPI3K-Akt pathwaySFKSrc kinasesapoptosissrctyrosine-protein kinase CSK

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