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Updated: Aug 15, 2025
07:47
Analysis of Brain Mitochondria Using Serial Block-Face Scanning Electron Microscopy
Published on: July 9, 2016
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Mitochondrial quality control in the brain: The physiological and pathological roles
Xurui Shen1, Peixin Sun1, Hao Zhang1
1Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Frontiers in Neuroscience
|December 29, 2022
Summary
Mitochondrial quality control (MQC) maintains brain energy homeostasis. Dysfunctional MQC causes brain diseases, but targeting MQC offers a promising therapeutic strategy for neurological disorders.
Area of Science:
- Neuroscience
- Cell Biology
- Biochemistry
Background:
- The brain's high energy demand necessitates robust energy homeostasis.
- Mitochondrial dysfunction is a key factor in various brain diseases.
- Mitochondrial quality control (MQC) is crucial for maintaining mitochondrial health and function.
Purpose of the Study:
- To summarize current knowledge on MQC in brain homeostasis.
- To evaluate MQC as a therapeutic target for brain disorders.
Main Methods:
- Literature review and synthesis of existing research on MQC.
- Analysis of MQC mechanisms and their role in brain pathophysiology.
- Identification of potential therapeutic targets within MQC pathways.
Main Results:
- MQC involves multiple coordinated mechanisms to ensure mitochondrial integrity.
- Aberrant MQC is linked to a spectrum of neurological and psychiatric disorders.
- MQC pathways present viable targets for therapeutic intervention.
Conclusions:
- Preserving mitochondrial function through MQC is vital for brain health.
- Targeting MQC pathways offers a promising strategy for treating brain diseases.
- Further research into MQC mechanisms can accelerate the development of novel therapies.
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