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Related Experiment Video

Updated: Aug 15, 2025

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Conventional and Threshold-Tracking Transcranial Magnetic Stimulation Tests for Single-handed Operation

Published on: August 16, 2021

PLUSPULS: A transcranial magnetic stimulator with extended pulse protocols.

Christoph Staat¹, Norbert Gattinger¹, Bernhard Gleich¹

¹Munich Institute of BioEngineering (MIBE) at Technical University of Munich (TUM) Boltzmannstra 11, 85748 Garching b. Muchen, Germany.

|December 29, 2022

Summary

This study details the PLUSPULS transcranial magnetic stimulation (TMS) device, a modular biphasic stimulator. Its enhanced design enables flexible, high-frequency pulse protocols for neuroscience research and clinical applications.

Keywords:

Biphasic Flexible Modular Transcranial magnetic stimulation ppTMS qTBS

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Last Updated: Aug 15, 2025

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Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Combined Transcranial Magnetic Stimulation and Electroencephalography of the Dorsolateral Prefrontal Cortex

Published on: August 17, 2018

Area of Science:

Neuroscience
Biomedical Engineering
Medical Devices

Background:

Transcranial magnetic stimulation (TMS) is a valuable tool in neuroscience and neurology.
Existing TMS devices have limitations in flexibility and advanced stimulation protocols.
There is a need for modular and adaptable TMS systems for research and clinical use.

Purpose of the Study:

To present the design and implementation of a modular, biphasic TMS device called PLUSPULS.
To enable advanced stimulation protocols, including high-frequency and paired-pulse stimulation.
To provide a flexible and adjustable TMS system for diverse research and clinical needs.

Main Methods:

Development of a modular hardware and firmware architecture for the PLUSPULS TMS.
Implementation of an enhanced charging network for efficient pulse capacitor charging.
Creation of a PC-based graphical user interface (GUI) for flexible control of stimulation parameters.

Main Results:

The PLUSPULS TMS successfully generates biphasic pulses with controlled amplitudes.
High-frequency stimulation with inter-stimulus intervals (ISI) down to 1ms is achieved.
The system supports complex pulse protocols such as paired pulse and quadri theta burst stimulation.

Conclusions:

The modular PLUSPULS TMS offers a flexible and adaptable platform for advanced neuromodulation.
The enhanced design facilitates easier adjustments for evolving research and clinical requirements.
This system expands the possibilities for diagnosing and treating neurological conditions using TMS.