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Related Experiment Video

Updated: Aug 15, 2025

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Author Spotlight: Studying Clinical Characters and Epilepsy Outcomes After Frontal Disconnection in Patients with MOGHE

Published on: August 16, 2024

Disconnection Syndromes.

Hakan Gürvit¹, Bedia Marangozoğlu Samancı¹

¹Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Noro Psikiyatri Arsivi

|December 29, 2022

Summary

Disconnection syndromes, a concept from Norman Geschwind, are now a leading model for neuropsychiatric disorders. Advances in brain imaging reveal network connectivity, enhancing our understanding of these conditions.

Keywords:

Disconnection syndromes Geschwind intrinsic connectivity networks neural networks

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Area of Science:

Neuroscience
Behavioral Neurology
Psychiatry

Background:

Disconnection syndromes, pioneered by Norman Geschwind, offer a framework for understanding neuropsychiatric disorders.
This paradigm has evolved significantly since its inception.

Purpose of the Study:

To review the historical development of disconnection syndromes.
To discuss the current status and future directions of this neuroscientific concept.

Main Methods:

Literature review of historical and contemporary research on disconnection syndromes.
Analysis of recent advancements in neuroimaging techniques, specifically network connectivity imaging.

Main Results:

Disconnection syndromes remain a dominant paradigm in explaining neuropsychiatric disorders.
Network connectivity imaging provides novel insights into the neural basis of these syndromes in living humans.

Conclusions:

The concept of disconnection syndromes continues to be a vital framework in behavioral neurology.
Modern neuroimaging techniques are crucial for advancing the study and clinical application of disconnection syndromes.