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Perforated duodenal ulcer secondary to deferasirox use in a child successfully managed with laparoscopic drainage: A

Abdullah Alshehri1, Tuqa Adil Alsinan2,3

  • 1Department of Surgery, College of Medicine, King Saud University, Riyadh 12372, Saudi Arabia. abalshehri@ksu.edu.sa.

World Journal of Clinical Cases
|December 29, 2022
PubMed

Insights

A perforated duodenal ulcer occurred in a 3-year-old treated with deferasirox for beta thalassemia major. Laparoscopic surgery was successful, highlighting the need for vigilance with this iron chelator.

Area of Science:

  • Pediatric Gastroenterology
  • Hematology
  • Surgical Case Reports

Background:

  • Perforated gastroduodenal ulcers are rare in children.
  • Deferasirox, an iron chelating agent, is a potential cause of gastroduodenal ulcers.
  • Beta-thalassemia major treatment often involves iron chelation therapy.

Observation:

  • A 3-year-old boy with beta-thalassemia major developed an acute abdomen.
  • Diagnostic workup revealed a perforated duodenal ulcer.
  • Laparoscopic exploration confirmed the diagnosis.

Findings:

  • The perforated duodenal ulcer was successfully managed with laparoscopic washout and drainage.
  • This case highlights a rare but serious gastrointestinal complication associated with deferasirox.
  • Minimally invasive surgery proved effective in this pediatric case.

Implications:

  • Early recognition and prevention of gastrointestinal issues are critical for children on deferasirox.
  • Laparoscopic surgery is a safe and feasible option for selected pediatric patients with perforated duodenal ulcers.
  • This case underscores the importance of considering medication side effects in pediatric emergencies.
Abstract

Keywords:
Case reportChildrenDeferasiroxHemoglobinopathiesIron chelating agentsPeptic ulcer

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