Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tissue Transplantation

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Practical Guide to Address Common Myths in the Pre- and Post-kidney Transplant Management of the Elderly Patient with Cancer: An Opinion Paper.

Transplantation direct·2026

Same author

Outcomes of Simultaneous Liver-Kidney Transplant and Kidney After Liver Transplant Using the Safety Net Criteria-A Single-center Experience.

Transplantation direct·2026

Same author

Tolerability and Effectiveness of Tirzepatide in Kidney Transplant Recipients: Real-world Experience From a Single-center Study.

Transplantation·2026

Same author

Assessing Deceased-Donor Kidneys Through Posttransplant Survival Prediction Algorithms.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2025

Same author

Long-Term Outcomes of BK Viremia in Kidney Transplant Recipients.

Clinical transplantation·2025

Same author

2025 Report of the Sensitization in Transplantation: Assessment of Risk Working Group on donor-derived cell-free DNA: Establishing analytical validity as the basis for appropriate and effective clinical utilization.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2025

Search research articles

Related Experiment Video

Updated: Aug 15, 2025

Murine Full-thickness Skin Transplantation

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

How to maximize graft survival.

Mary Ann Lim¹, Roy D Bloom

¹Renal-Electrolyte and Hypertension Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.

Current Opinion in Organ Transplantation

|December 29, 2022

Summary

This summary is machine-generated.

Maximizing kidney transplant graft survival involves optimizing immunosuppression and managing recurrent diseases. Strategies include personalized immunosuppression, addressing specific kidney diseases, and slowing allograft injury with blood pressure control and SGLT-2 inhibitors.

More Related Videos

Optimization of the Cuff Technique for Murine Heart Transplantation

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Related Experiment Videos

Last Updated: Aug 15, 2025

Murine Full-thickness Skin Transplantation

Murine Full-thickness Skin Transplantation

Published on: January 2, 2017

Optimization of the Cuff Technique for Murine Heart Transplantation

Optimization of the Cuff Technique for Murine Heart Transplantation

Published on: June 26, 2020

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Xenograft Skin Model to Manipulate Human Immune Responses In Vivo

Published on: June 29, 2022

Area of Science:

Nephrology
Transplantation immunology

Background:

Kidney transplant failure leads to poor patient outcomes, increased costs, and organ shortages.
Optimizing graft survival is critical for recipients.

Approach:

This review examines strategies to maximize kidney graft survival.
Key areas include immunosuppression optimization, recurrent disease management, and chronic kidney disease strategies.

Key Points:

Tailoring immunosuppression to individual patients prevents over/under-immunosuppression and drug toxicities.
Recent findings cover focal segmental glomerulosclerosis, membranous nephropathy, complement-mediated kidney disease, and monoclonal gammopathy of renal significance.
Approaches to slow allograft injury include blood pressure control, antiproteinuric agents, and SGLT-2 inhibitors.

Conclusions:

Advances in immunosuppression have improved allograft outcomes over the past two decades.
Future improvements are anticipated due to increased focus on kidney disease, biomarkers, genetic testing, and machine learning.