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The Establishment of a Murine Mandibular Molar Extraction Socket Healing Model
Published on: January 13, 2023
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Does platelet-rich fibrin increase bone regeneration in mandibular third molar extraction sockets?
Azuka Raphael Njokanma1, Olawunmi Adedoyin Fatusi2, Olufemi Kolawole Ogundipe2
1Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria.
Journal of the Korean Association of Oral and Maxillofacial Surgeons
|December 29, 2022
Summary
Platelet-rich fibrin (PRF) did not significantly enhance bone regeneration in extraction sockets after third molar removal. However, patient sex, impaction type, and surgery duration impacted bone formation rates.
Area of Science:
- Oral surgery
- Regenerative medicine
- Dental implantology
Background:
- Impacted mandibular third molar extractions are common surgical procedures.
- Socket preservation techniques aim to maintain alveolar bone volume post-extraction.
- Platelet-rich fibrin (PRF) is a bioactive autologous material used to promote tissue healing.
Purpose of the Study:
- To evaluate the efficacy of platelet-rich fibrin (PRF) in promoting bone regeneration within extraction sockets.
- To analyze the patterns and influencing factors of bone regeneration after impacted mandibular third molar surgery.
Main Methods:
- A prospective study randomized 90 patients into PRF and non-PRF groups.
- PRF was placed in extraction sockets for the intervention group; control group received standard suturing.
- Periapical radiographs analyzed bone regeneration at 1, 4, 8, and 12 weeks post-surgery.
Main Results:
- No statistically significant difference in bone regeneration (RNFB%) was observed between PRF and non-PRF groups.
- Bone formation was highest in the middle third of the socket in both groups.
- Patient sex, impaction type, and surgery duration significantly correlated with bone formation percentage.
Conclusions:
- PRF placement did not significantly improve socket bone regeneration compared to standard care.
- Factors such as patient sex, impaction complexity, and surgical time influence bone healing outcomes.
- Further research may explore optimized PRF application or alternative regenerative strategies.
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