Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Antibody Actions

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hypervalent iodine-mediated cyclization of <i>N</i>-vinyl amides for the synthesis of 4-functionalized dihydrooxazolines.

Organic & biomolecular chemistry·2026

Same author

6-Isoprenylindole-3-carboxylic Acid with an Anti-Melanogenic Activity from a Marine-Derived <i>Streptomyces</i> sp. APA-053.

Marine drugs·2025

Same author

Trifluoromethylative and Pentafluoroethylative Heterofunctionalization (C-O, C-S, and C-N) of Alkenes Using Visible Light Photocatalysis.

ACS omega·2024

Same author

Copper-Catalyzed Diamination of Alkenes using <i>o</i>-Benzoylhydroxylamines to Access the Four Azaindoline Families.

Organic letters·2024

Same author

Modulation of Amyloid and Tau Aggregation to Alleviate Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease.

ACS pharmacology & translational science·2024

Same author

Photocatalytic intermolecular bromonitroalkylation of styrenes: synthesis of cyclopropylamine derivatives and their evaluation as LSD1 inhibitors.

RSC advances·2024

Search research articles

Related Experiment Video

Updated: Aug 15, 2025

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Degrader-Antibody Conjugates: Emerging New Modality.

Ki Bum Hong¹, Hongchan An¹

¹New Drug Development Center (NDDC), Daegu-Gyeongbuk Medical Innovation Foundation (DGMIF), 80 Cheombok-ro, Dong-gu, 41061 Daegu, Korea.

Journal of Medicinal Chemistry

|December 29, 2022

Summary

Degrader-antibody conjugates (DACs) merge drug delivery with target protein degradation for enhanced cancer therapy. This innovative approach improves toxin delivery and therapeutic index, with early clinical trials underway.

More Related Videos

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

Related Experiment Videos

Last Updated: Aug 15, 2025

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Chemical Conjugation of a Purified DEC-205-Directed Antibody with Full-Length Protein for Targeting Mouse Dendritic Cells In Vitro and In Vivo

Published on: February 5, 2021

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Initial Evaluation of Antibody-conjugates Modified with Viral-derived Peptides for Increasing Cellular Accumulation and Improving Tumor Targeting

Published on: March 8, 2018

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

Area of Science:

Bioconjugation Chemistry
Oncology Therapeutics
Molecular Targeted Therapy

Background:

Small-molecule-drug conjugates (SMDCs) and antibody-drug conjugates (ADCs) enhance chemotherapeutic delivery and therapeutic index.
Target protein degradation (TPD) offers a novel mechanism for disease treatment.
The limitations of existing drug delivery systems necessitate innovative solutions.

Purpose of the Study:

To introduce the emerging field of degrader-antibody conjugates (DACs).
To elucidate the fundamental concepts and applications of DACs.
To review recent advancements and clinical progress in DAC technology.

Main Methods:

Literature review of SMDCs, ADCs, and TPD strategies.
Analysis of the conjugation of small molecule degraders with antibodies.
Examination of preclinical and clinical data on DACs.

Main Results:

DACs combine targeted delivery via antibodies with potent protein degradation.
This dual mechanism offers improved efficacy and selectivity over traditional conjugates.
Early-stage clinical trials demonstrate the potential of DACs in cancer treatment.

Conclusions:

DACs represent a promising next-generation therapeutic modality.
The field is rapidly advancing, with significant potential for clinical translation.
Further research into DAC design and application is warranted.