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Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
An update on inflammation in antiphospholipid syndrome
Amala Ambati1, Yu Zuo, Jason S Knight
1Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Antiphospholipid syndrome (APS) involves blood clots and inflammation. Recent research highlights endothelial cell activation, complement, and neutrophils in APS, offering new therapeutic targets for personalized treatment.
Area of Science:
- Immunology
- Pathophysiology
- Thrombosis
Background:
- Antiphospholipid syndrome (APS) is an acquired thrombo-inflammatory disorder.
- Characterized by circulating antiphospholipid antibodies (aPL) and diverse clinical outcomes.
- Pathogenesis involves complex interactions leading to thrombosis and inflammation.
Conclusions:
- Understanding APS pathophysiology is key to developing targeted therapies.
- Novel insights into endothelial, complement, and neutrophil roles offer therapeutic potential.
- Multiomics approaches may enable patient stratification and personalized treatment strategies.
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