Intravascular Lithotripsy in Peripheral Artery Disease
Carlos E Vazquez Sosa1, Aaqib Malik1, Jayakumar Sreenivasan1
1From the Department of Cardiology, Westchester Medical Center, New York Medical College, Valhalla, NY.
Cardiology in Review
|December 29, 2022
Summary
Intravascular lithotripsy (IVL) offers a novel, low-risk solution for treating calcified peripheral artery disease. This ultrasound-based therapy effectively fractures calcium, enabling successful revascularization with promising safety data from initial trials.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Medical Devices
Background:
- Peripheral artery disease (PAD) impacts millions globally, increasing morbidity and mortality.
- Heavily calcified lesions pose significant challenges for interventional operators, with existing atherectomy devices carrying risks of complications like dissection and perforation.
Purpose of the Study:
- To evaluate the safety and effectiveness of Intravascular Lithotripsy (IVL) as a novel treatment modality for heavily calcified peripheral artery disease.
- To assess the procedural risks associated with IVL compared to traditional atherectomy devices.
Main Methods:
- Intravascular lithotripsy (IVL) utilizes a balloon catheter emitting high-energy ultrasound waves to fracture calcified plaques.
- Published data from five trials, including studies in common femoral and infrapopliteal arteries, were reviewed.
Main Results:
- IVL demonstrated encouraging safety and effectiveness in treating calcified stenoses.
- The available data indicate minimal procedural risk associated with IVL compared to existing atherectomy methods.
Conclusions:
- Intravascular lithotripsy presents a promising, low-risk option for revascularizing complex calcified peripheral artery disease.
- Further large-scale studies are warranted to fully understand the long-term outcomes and potential risks of IVL therapy.
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